methyl 4-(1,2,3,4-tetrahydronaphthalen-1-yl)benzoate | 132777-26-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: methyl 4-(1,2,3,4-tetrahydronaphthalen-1-yl)benzoate
• CAS: 132777-26-5
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: RURNNYDZGFGQJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-phenylpropyl-magnesium bromide 在 四氯化钛 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 1.75h， 生成 methyl 4-(1,2,3,4-tetrahydronaphthalen-1-yl)benzoate
  参考文献：
  名称：

  A systematic study of benzyl cation initiated cyclization reactions

  摘要：

  A systematic investigation of benzyl cation initiated cyclization reactions to form six-membered carbocycles is presented. The generation of benzyl cations from benzylic bromides, ethers, and alcohols followed by intramolecular capture provided good yields of cyclized products by use of several different cyclization terminators (e.g., phenyl, alkene, beta-keto ester). A study on the effect of changing the electronic nature of substituents para to the benzyl cation showed that even electron-withdrawing substituents such as quaternary ammonium afford high yields of cyclization products. The formation of five- and seven-membered carbocycles was briefly investigated and found to be less general than the formation of the corresponding six-membered carbocycles.

  DOI：

  10.1021/jo00008a049

文献信息

• BH ₃  ⋅ Me ₂ S: An Alternative Hydride Source for NiH‐Catalyzed Reductive Migratory Hydroarylation and Hydroalkenylation of Alkenes
  作者：Jiandong Liu、Hegui Gong、Shaolin Zhu

  DOI：10.1002/ejoc.202100005

  日期：2021.3.12

  The inexpensive borane dimethylsulfide (BMS) complex was found to be an efficient hydride source for nickel‐hydride catalyzed migratory hydrofunctionalization. Using BMS, migratory hydroarylation and migratory hydroalkenylation were achieved with broad substrate scope under mild conditions.

  廉价的硼烷二甲基硫醚（BMS）络合物被发现是氢化镍催化迁移性加氢官能化的有效氢化物来源。使用BMS，在温和条件下，在较宽的底物范围内实现了迁移加氢芳基化和迁移加氢烯基化。
• Synthesis of 1-Aryltetralins via Re₂O₇/HReO₄ Mediated Intramolecular Hydroarylations
  作者：Rukhsar Gul、Liqun Hu、Yibing Liu、Youwei Xie

  DOI：10.1021/acs.joc.3c00639

  日期：2023.8.18

  Here, we describe highly efficient intramolecular hydroarylations mediated by Re2O7/HReO4. Styrene derivatives of different electronic properties have been activated to effect a challenging intramolecular hydroarylation for the facile access to various substituted 1-aryltetralin structures. This method is characterized by mild reaction conditions, broad substrate scope, high chemical yields, and 100%

  在这里，我们描述了由 Re 2 O 7 /HReO 4介导的高效分子内加氢芳基化。不同电子特性的苯乙烯衍生物已被激活，以实现具有挑战性的分子内加氢芳基化，从而轻松获得各种取代的 1-芳基四氢化萘结构。该方法具有反应条件温和、底物范围广、化学收率高、原子经济性100%等特点。iso CA-4 类似物的有效全合成例证了该方法的潜在合成应用。
• ANGLE, STEVEN R.;LOUIE, MICHAEL S., J. ORG. CHEM., 56,(1991) N, C. 2853-2866
  作者：ANGLE, STEVEN R.、LOUIE, MICHAEL S.

  DOI：——

  日期：——
• N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS
  申请人：Abbott Laboratories

  公开号：EP1318978A2

  公开（公告）日：2003-06-18
• [EN] N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS<br/>[FR] PROMOTEURS DE L'APOPTOSE A BASE DE N-ACYLSULFONAMIDES
  申请人：ABBOTT LAB

  公开号：WO2002024636A2

  公开（公告）日：2002-03-28

  N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.