o-phenylenedioxydiacetic acid | 93439-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-phenylenedioxydiacetic acid
• 英文别名: 2,2'-dihydroxy-2,2'-o-phenylene-di-acetic acid；2,2'-Dihydroxy-2,2'-o-phenylen-di-essigsaeure；α.α'-Dioxy-o-phenylendiessigsaeure；o-Phenylendiglycolsaeure；2-[2-[Carboxy(hydroxy)methyl]phenyl]-2-hydroxyacetic acid
• CAS: 93439-58-8
• 化学式: C₁₀H₁₀O₆
• 分子量: 226.186
• InChiKey: HYCNRDZKNBPHTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  o-phenylenedioxydiacetic acid 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Challenor; Ingold, Journal of the Chemical Society, 1923, vol. 123, p. 2075

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-苯二乙腈 在 五氯化磷 、 硫酸 作用下， 生成 o-phenylenedioxydiacetic acid
  参考文献：
  名称：

  Challenor; Ingold, Journal of the Chemical Society, 1923, vol. 123, p. 2075

  摘要：

  DOI：

文献信息

• COMPOUND, DISPERSANT AND TONER
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160130233A1

  公开（公告）日：2016-05-12

  The present invention provides a dispersant excellent in the solubility to a solvent, the adsorption power to a coloring material, and the coloring material dispersibility, and reduced in the self-coloring property, a compound and a polymerizable compound for preparing the dispersant, and a toner using the dispersant. The dispersant has a structure in which a structure represented by the following specific formula (3) or a tautomer thereof is bonded with a polymer, and the toner contains the dispersant.

  本发明提供了一种分散剂，具有优异的溶解性、对染料的吸附能力和染料分散性，同时减少了自着色性，以及用于制备分散剂的化合物和可聚合化合物，以及使用该分散剂的色调剂。该分散剂具有以下特定公式（3）所表示的结构或其互变异构体与聚合物结合的结构，色调剂中包含该分散剂。
• Method of preventing adhesions with absorbable polyoxaesters
  申请人：——

  公开号：US20010012511A1

  公开（公告）日：2001-08-09

  The present invention describes a method of preventing adhesion formation between tissues in an animal by placing a sterile polyoxaester adhesion prevention barrier between the tissues of the animal to prevent an adhesion from forming.

  本发明描述了一种通过在动物的组织之间放置无菌聚氧酯粘连预防屏障来防止组织间粘连形成的方法。
• Syntheses, crystal structure and magnetocaloric effect of [Gd(PDOA)(NO3)(H2O)2]n
  作者：Juraj Černák、Katarína Harčárová、Martin Uličný、Róbert Tarasenko、Martin Orendáč、Larry R. Falvello

  DOI：10.1016/j.molstruc.2017.02.028

  日期：2017.6

  decacoordination by oxygen atoms from hexadentate PDOA ligands with chelating and bridging functions, a chelating nitrato ligand and two aqua ligands. Intra- and intermolecular hydrogen bonds of the O H⋯O and C H⋯O types contribute to the stability of the structure. The temperature dependence of the magnetic susceptibility revealed weak magnetic interactions among Gd(III) ions which may be attributed

  摘要 配位聚合物 [Gd(PDOA)(NO3)(H2O)2]n (1) (PDOA = 邻苯二氧二乙酸酯) 已制备并进行光谱和结构表征。其晶体结构由 Gd(III) 原子的带状排列形成，这些原子通过桥接羧酸根连接并位于 Gd⋯Gd 距离约为 6.1 A 的稠合三角形的尖端。 Gd(III) 中心原子表现出脱配位来自具有螯合和桥接功能的六齿 PDOA 配体、一个螯合硝基配体和两个水配体的氧原子。OH⋯O 和 CH⋯O 类型的分子内和分子间氢键有助于结构的稳定性。磁化率的温度依赖性揭示了 Gd(III) 离子之间的弱磁相互作用，这可能归因于偶极耦合。
• MEDICAL INSTRUMENT
  申请人：TERUMO Kabushiki Kaisha

  公开号：EP4026572A1

  公开（公告）日：2022-07-13

  The present invention provides a means for improving the durability (sliding durability, in particular) of a surface lubrication layer of a medical instrument, while maintaining the flexibility of the instrument. This medical instrument comprises: a substrate in which a portion of the surface thereof is a polyester resin; a middle layer that is formed at least on a portion of the surface of the substrate and that includes a (meth)acrylic modified polyester resin and a polyurethane resin; and a surface lubricating layer that is formed on top of the middle layer and that includes a block copolymer having a structural unit (A) derived from hydrophobic monomers and a structural unit (B) derived from hydrophilic monomers. The hydrophobic monomers and/or the hydrophilic monomers have a (meth)acryloyl group.

  本发明提供了一种提高医疗器械表面润滑层耐久性（尤其是滑动耐久性）的方法，同时保持了医疗器械的柔韧性。该医疗器械包括：基底，其中部分表面为聚酯树脂；中间层，至少形成于基底的部分表面，包括（甲基）丙烯酸改性聚酯树脂和聚氨酯树脂；以及表面润滑层，形成于中间层之上，包括嵌段共聚物，其结构单元（A）来自疏水单体，结构单元（B）来自亲水单体。疏水单体和/或亲水单体具有一个（甲基）丙烯酰基。
• Macromolecules
  申请人：STARPHARMA PTY LTD

  公开号：US10265409B2

  公开（公告）日：2019-04-23

  A macromolecule includes i) a dendrimer with a core and at least one generation of lysine residue building units, the outermost generation of building units having surface amino groups, ii) a first terminal group covalently attached to a first surface amino group of a building unit, which includes a residue of docetaxel (DTX), and iii) a second terminal group covalently attached to a second surface amino group of a building unit, which includes a pharmacokinetic modifying agent. The pharmacokinetic modifying agent can be a polyethylene glycol (PEG). The first terminal group can be covalently attached to the surface amino group of the dendrimer through a diacid linker. The diacid linker can include a 2,2′-thiodiacetic acid residue. The diacid linker can form an ester bond with a hydroxyl group of the DTX and an amide bond with the surface amino group. A pharmaceutically acceptable salt of the macromolecule can be prepared.

  一种大分子包括 i) 树枝状聚合物，具有核心和至少一代赖氨酸残基构建单元，最外层的构建单元具有表面氨基；ii) 与构建单元的第一表面氨基共价连接的第一末端基团，其中包括多西他赛（DTX）残基；iii) 与构建单元的第二表面氨基共价连接的第二末端基团，其中包括药代动力学修饰剂。药代动力学修饰剂可以是聚乙二醇（PEG）。第一末端基团可通过二酸连接剂共价连接到树枝状聚合物的表面氨基上。二酸连接体可包括 2,2′-硫代乙酸残基。二酸连接体可与 DTX 的羟基形成酯键，与表面氨基形成酰胺键。可以制备大分子的药学上可接受的盐。