5-iodo-2H-3,1-benzoxazine-2,4(1H)-dione | 32615-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 5-iodo-2H-3,1-benzoxazine-2,4(1H)-dione
• 英文别名: 6-(Iodo)isatoic anhydride；5-iodo-1H-3,1-benzoxazine-2,4-dione
• CAS: 32615-82-0
• 化学式: C₈H₄INO₃
• 分子量: 289.029
• InChiKey: RAADLXMPZLKGDQ-UHFFFAOYSA-N

物化性质

• 熔点：
  173.5 °C(Solv: methanol (67-56-1); benzene (71-43-2))
• 密度：
  2.088±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-iodo-2H-3,1-benzoxazine-2,4(1H)-dione 生成 3,4-dihydro-6-iodo-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
  参考文献：
  名称：

  Aust. J. Chem. 1999, 52, 1061-1069

  摘要：

  DOI：
• 作为产物：
  描述：

  4-碘靛红 生成 5-iodo-2H-3,1-benzoxazine-2,4(1H)-dione
  参考文献：
  名称：

  Pyridazinedione compounds useful in treating neurological disorders

  摘要：

  本发明涉及吡啶并[4,5-b]喹啉及其药用盐，它们是兴奋性氨基酸拮抗剂，在需要此类拮抗作用时非常有用，例如在治疗神经系统疾病时。该发明还提供含有吡啶并[4,5-b]喹啉作为活性成分的药物组合物，以及治疗神经系统疾病的方法。

  公开号：

  US05599814A1

文献信息

• Pyridazinedione compounds useful in treating neurological disorders
  申请人：Imperial Chemical Industries, PLC

  公开号：US05599814A1

  公开（公告）日：1997-02-04

  The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.

  本发明涉及吡啶并[4,5-b]喹啉及其药用盐，它们是兴奋性氨基酸拮抗剂，在需要此类拮抗作用时非常有用，例如在治疗神经系统疾病时。该发明还提供含有吡啶并[4,5-b]喹啉作为活性成分的药物组合物，以及治疗神经系统疾病的方法。
• Benzodiazepine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04405516A1

  公开（公告）日：1983-09-20

  There is provided imidazodiazepines of the formula ##STR1## wherein R.sup.1 is methyl, ethyl or isopropyl, one of R.sup.4 and R.sup.5 is hydrogen and the other is nitro or cyano, and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are dimethylene, trimethylene or propenylene and the carbon atom denoted as .gamma. has the (S)- or (R,S)- configuration, and X is an oxygen or sulphur atom, and their pharmaceutically acceptable acid addition salts. The compounds are useful in the antagonization of the central-depressant muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of indication, for example of schistosomicidally-active 1,4-benzodiazepines. Also provided are methods for making the compounds.

  提供的是公式为##STR1##的咪唑二氮平类化合物，其中R.sup.1是甲基、乙基或异丙基，R.sup.4和R.sup.5中的一个是氢，另一个是硝基或氰基，R.sup.2是氢，R.sup.3是氢或低碳基，或者R.sup.2和R.sup.3一起是二甲亚烷、三甲亚烷或丙烯亚烷，被标记为γ的碳原子具有(S)-或(R,S)-构型，X是氧或硫原子，以及它们的药学上可接受的酸盐。这些化合物在拮抗具有镇静作用的1,4-苯二氮平的中枢抑制肌肉松弛、共济失调、降低血压和呼吸抑制性质方面非常有用。它们也可以用于抑制1,4-苯二氮平在其他适应症领域中对中枢神经系统的作用，例如对血吸虫活性的1,4-苯二氮平。同时还提供了制备这些化合物的方法。
• Imidazo[1,5a][1,4]benzodiazepines
  申请人：Hoffmann-La Roche Inc.

  公开号：US04386028A1

  公开（公告）日：1983-05-31

  There is provided imidazodiazepines of the formula ##STR1## wherein R.sup.1 is methyl, ethyl or isopropyl, one of R.sup.4 and R.sup.5 is hydrogen and the other is nitro or cyano, and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are dimethylene, trimethylene or propenylene and the carbon atom denoted as .gamma. has the (S)- or (R,S)-configuration, and X is an oxygen or sulphur atom, and their pharmaceutically acceptable acid addition salts. The compounds are useful in the antagonization of the central-depressant muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of indication, for example of schistosomicidally-active 1,4-benzodiazepines. Also provided are methods for making the compounds.

  提供的为公式##STR1##中的咪唑二氮平，其中R.sup.1是甲基、乙基或异丙基，R.sup.4和R.sup.5中的一个是氢，另一个是硝基或氰基，而R.sup.2是氢并且R.sup.3是氢或低碳基，或者R.sup.2和R.sup.3一起是二亚甲基、三亚甲基或丙烯亚甲基，而被表示为γ的碳原子具有（S）-或（R，S）-构型，X是氧或硫原子，并且它们的药学上可接受的酸盐也提供了。这些化合物可用于拮抗具有镇静作用的1,4-苯二氮平的中枢抑制肌肉松弛、共济失调、降压和呼吸抑制特性。它们还可用于抑制在其他适应症领域中使用的1,4-苯二氮平对中枢神经系统的活动，例如对于血吸虫活性的1,4-苯二氮平。还提供了制备这些化合物的方法。
• Imidazobenzodiazepines
  申请人：Hoffmann-La Roche Inc.

  公开号：US04489003A1

  公开（公告）日：1984-12-18

  There are described novel pharmaceutically active substances which have a pronounced affinity to the central benzodiazepine receptors and which have only a low toxicity. These active substances, namely imidazobenzodiazepines of the formula ##STR1## wherein A is lower alkylene, n is zero or 1, R.sup.1 is lower alkynyl, lower alkenyl, aryl, (C.sub.3-8)-cycloalkyl optionally substituted by lower alkyl or (C.sub.5-8)-cycloalkenyl optionally substituted by lower alkyl, or a 5- or 6-membered saturated or unsaturated heterocycle which contains an oxygen or sulphur atom as a ring member and which is optionally substituted by lower alkyl, R.sup.4 and R.sup.5 each are hydrogen, halogen, trifluoromethyl, cyano, nitro, amino or lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is lower alkyl or R.sup.2 and R.sup.3 together are dimethylene, trimethylene or propenylene, the compounds of formula I in which R.sup.2 and R.sup.3 together are dimethylene, trimethylene or propenylene having the (S) or (R,S) configuration with reference to the carbon atom denoted by .gamma., and their pharmaceutically acceptable acid addition salts, can be used as medicaments in the form of pharmaceutical preparations, especially in the control of convulsions and anxiety states and/or in the partial or complete antagonization of some or all activities which 1,4-benzodiazepines having tranquillizing activity or other substances display via the central benzodiazepine receptors.

  本文描述了一种新型药物活性物质，其对中枢苯二氮平受体具有显著的亲和力，且毒性较低。这些活性物质是公式I中的咪唑苯二氮平，其中A为较低的烷基，n为零或1，R1为较低的炔基、较低的烯基、芳基、(C3-8)-环烷基（可选地被较低的烷基取代）或(C5-8)-环烯基（可选地被较低的烷基取代）、或含有氧或硫原子作为环成员的5-或6-成员饱和或不饱和杂环，且可选地被较低的烷基取代，R4和R5分别为氢、卤素、三氟甲基、氰基、硝基、氨基或较低的烷基，而R2为氢且R3为较低的烷基或R2和R3一起为二甲亚烷、三甲亚烷或丙烯亚烷，公式I中R2和R3一起为二甲亚烷、三甲亚烷或丙烯亚烷的化合物相对于被标记为γ的碳原子具有(S)或(R,S)构型，它们的药学上可接受的酸盐加合物可以作为药物制剂使用，特别是在控制惊厥和焦虑状态和/或部分或完全拮抗一些或所有1,4-苯二氮平具有镇静作用或其他物质通过中枢苯二氮平受体显示的活性方面。
• Imidazo-benzodiazepines and their use
  申请人：Hoffmann-La Roche Inc.

  公开号：US04352815A1

  公开（公告）日：1982-10-05

  There is provided imidazodiazepines of the formula ##STR1## wherein R.sup.1 is methyl, ethyl or isopropyl, one of R.sup.4 and R.sup.5 is hydrogen and the other is nitro or cyano, and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are dimethylene, trimethylene or propenylene and the carbon atom denoted as .gamma. has the (S)-- or (R,S)-- configuration, and X is an oxygen or sulphur atom, and their pharmaceutically acceptable acid addition salts. The compounds are useful in the antagonization of the central-depressant muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of indication, for example of schistosomicidally-active 1,4-benzodiazepines. Also provided are methods for making the compounds.

  提供了公式为##STR1##的咪唑二氮平类化合物，其中R.sup.1是甲基、乙基或异丙基，R.sup.4和R.sup.5中的一个是氢，另一个是硝基或氰基，而且R.sup.2是氢且R.sup.3是氢或低碳基，或者R.sup.2和R.sup.3一起是二甲亚ethylene、三亚甲ethylene或丙烯亚基，而被标记为γ的碳原子具有(S)-或(R,S)-构型，X是氧或硫原子，以及它们的药用可接受酸盐。这些化合物对于拥有镇静作用的1,4-苯二氮平的中枢抑制肌肉松弛、共济失调、降低血压和呼吸抑制性能具有拮抗作用。它们还可用于抑制1,4-苯二氮平在其他指示领域中使用的中枢神经系统活性，例如对于血吸虫活性的1,4-苯二氮平。还提供了制备这些化合物的方法。