2,2'-(1,3-phenylenedimethylidyne) bis(hydrazinecarboximidamide) | 81913-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-(1,3-phenylenedimethylidyne) bis(hydrazinecarboximidamide)
• 英文别名: 2-[[3-[(Diaminomethylidenehydrazinylidene)methyl]phenyl]methylideneamino]guanidine
• CAS: 81913-34-0
• 化学式: C₁₀H₁₄N₈
• 分子量: 246.275
• InChiKey: XMHHBYPIBVIERY-UHFFFAOYSA-N

物化性质

• 沸点：
  447.2±55.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间苯二甲醛 、 肼甲酰亚胺酰胺一氯化氢 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 2,2'-(1,3-phenylenedimethylidyne) bis(hydrazinecarboximidamide)
  参考文献：
  名称：

  New furin inhibitors based on weakly basic amidinohydrazones

  摘要：

  A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K-i values of 0.46 and 0.59 mu M, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.092

文献信息

• New furin inhibitors based on weakly basic amidinohydrazones
  作者：Frank Sielaff、Manuel E. Than、Dorian Bevec、Iris Lindberg、Torsten Steinmetzer

  DOI：10.1016/j.bmcl.2010.11.092

  日期：2011.1

  A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K-i values of 0.46 and 0.59 mu M, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups. (C) 2010 Elsevier Ltd. All rights reserved.