2-甲基庚-6-烯腈 | 88364-59-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-甲基庚-6-烯腈
• 英文名称: 2-methylhept-6-enenitrile
• CAS: 88364-59-4
• 化学式: C₈H₁₃N
• 分子量: 123.198
• InChiKey: IPMNRFISFJTCBD-UHFFFAOYSA-N

物化性质

• 沸点：
  207.3±19.0 °C(Predicted)
• 密度：
  0.824±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-甲基庚-6-烯腈 在 Grubbs catalyst first generation 二异丁基氢化铝 、 potassium carbonate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 1-Ethenyl-6-methyl-6-(4-methylpent-4-enyl)cyclohexene
  参考文献：
  名称：

  An expedient enyne metathesis approach to dysidiolide

  摘要：

  A short and efficient enyne metathesis route is reported for the construction of a key intermediate required in the synthesis of dysidiolide thus completing its formal synthesis. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.043
• 作为产物：
  描述：

  在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到2-甲基庚-6-烯腈
  参考文献：
  名称：

  硅定向的贝克曼碎裂。三甲基甲硅烷基三氟甲磺酸酯催化裂解环状β-三甲基甲硅烷基酮肟乙酸酯

  摘要：

  环状（E）-β-三甲基甲硅烷基酮肟乙酸酯可通过三甲基甲硅烷基三氟甲磺酸酯的催化作用有效裂解，得到相应的不饱和腈。贝克曼重排中的断裂完全由三甲基甲硅烷基控制和引导，从而导致双键的区域和立体特异性形成。

  DOI：

  10.1016/s0040-4039(00)88252-0

文献信息

• Avoiding Olefin Isomerization During Decyanation of Alkylcyano α,ω-Dienes: A Deuterium Labeling and Structural Study of Mechanism
  作者：Giovanni Rojas、Kenneth B. Wagener

  DOI：10.1021/jo800640j

  日期：2008.7.1

  pathway involving decyanation chemistry for the synthesis of pure alkyl α,ω-dienes in quantitative yields is presented. Prior methodologies for the preparation of such compounds required 6−9 steps, sometimes leading to product mixtures resulting from olefin isomerization chemistry. This isomerization chemistry has been eliminated. Deuteration labeling and structural mechanistic investigations were completed

  提出了一种涉及脱氰化学的两步合成途径，以定量收率合成纯烷基α，ω-二烯。用于制备此类化合物的现有方法学需要6-9个步骤，有时会由于烯烃异构化化学反应而产生产物混合物。消除了这种异构化化学反应。完成氘化标记和结构机理研究以破译这种化学反应。氘标记实验揭示了这种自由基脱氰化学的精确性质，其中醇起着氢供体的作用。本文报道了避免竞争性分子内环化的正确分子设计，以及在脱氰过程中避免烯烃异构化的必要反应条件。
• Silicon-directed beckmann fragmentation
  作者：Hisao Nishiyama、Koji Sakuta、Noriyuki Osaka、Hiriyuki Arai、Makoto Matsumoto、Kenji Itoh

  DOI：10.1016/s0040-4020(01)81693-8

  日期：1988.1

  selective fragmentation reactions of β-trimethylsilylketoximes have been proved to proceed effectively with acid catalysts giving the corresponding nitriles. Cyclic silylketoximes gave unsaturated nitriles. The fragmentation in the Beckmann rearrangement is completely controlled and directed by a trimethylsilyl group to lead the regio- and stereo-specific formation of the double bond. The catalytic fragmentation

  业已证明，使用酸催化剂可有效地进行β-三甲基甲硅烷基酮肟的选择性裂解反应，得到相应的腈。环状甲硅烷基酮肟产生不饱和腈。贝克曼重排中的断裂完全由三甲基甲硅烷基控制和引导，从而导致双键的区域特异性和立体特异性形成。通过三甲基甲硅烷基酮肟肟乙酸酯和三甲基甲硅烷基三氟甲磺酸酯的组合进行催化裂解，从而以高收率得到腈。讨论了基于立体化学结果的片段的出色的立体特异性。还介绍了一些昆虫信息素的简单立体控制合成方法。
• NISHIYAMA, HISAO;SAKUTA, KOJI;OSAKA, NORIYUKI;ARAI, HIROYUKI;MATSUMOTO, M+, TETRAHEDRON, 44,(1988) N, C. 2413-2426
  作者：NISHIYAMA, HISAO、SAKUTA, KOJI、OSAKA, NORIYUKI、ARAI, HIROYUKI、MATSUMOTO, M+

  DOI：——

  日期：——
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition containing the copolymer and uses thereof
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1734061B1

  公开（公告）日：2010-04-07
• Polar group-containing olefin copolymer, process for preparing the same, thermoplastic resin composition containing the copolymer, and uses thereof
  申请人：Imuta Junichi

  公开号：US20090137757A1

  公开（公告）日：2009-05-28

  A polar group-containing olefin copolymer having excellent adhesion properties to metals or polar resins and excellent compatibility therewith, a process for preparing the copolymer, a thermoplastic resin composition containing the copolymer, and uses thereof. The polar group-containing olefin copolymer comprises a constituent unit derived from an □-olefin of 2 to 20 carbon atoms, and a constituent unit derived from a straight-chain, branched or cyclic polar group-containing monomer having at the end a polar group such as a hydroxyl group or an epoxy group and/or a constituent unit derived from a macromonomer having at the end a polymer segment obtained by anionic polymerization, ring-opening polymerization or polycondensation. The polar group-containing olefin copolymer can be prepared by polymerizing the α-olefin with the polar group-containing monomer and/or the macromonomer in the presence of a metallocene catalyst. The polar group-containing olefin copolymer and the thermoplastic resin composition containing the copolymer are used for films, sheets, modifiers, building/civil engineering materials, automobile exterior trim, electric/electronic parts, coating bases, compatibilizing agents, etc.