Methyl-aethyl-<2-methyl-benzyl>-amin | 91338-96-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl-aethyl-<2-methyl-benzyl>-amin
• 英文别名: Methyl-aethyl-(2-methyl-benzyl)-amin；Ethyl-methyl-(o-tolyl-methyl)-amine；N-methyl-N-[(2-methylphenyl)methyl]ethanamine
• CAS: 91338-96-4
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: TWNMQODKUPZLLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Benzyl-ethyl-methyl-(trimethylsilylmethyl)azanium;iodide 在 cesium fluoride 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 23.0h， 生成 ethyl-methyl-phenethyl-amine 、 Methyl-aethyl-<2-methyl-benzyl>-amin
  参考文献：
  名称：

  Ylide rearrangement of benzyltrialkylammonium salts: the improved Sommelet-Hauser rearrangement

  摘要：

  DOI：

  10.1021/jo00236a041

文献信息

• 3-SUBSTITUTED-6-ARYL PYRIDINES
  申请人：Hutchinson Alan J.

  公开号：US20110281837A1

  公开（公告）日：2011-11-17

  3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I的3-取代-6-芳基吡啶化合物：其中R1、R2、R3、R8、R9、A和Ar的定义在此处。这些化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合到C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的制药组合物，以及将这些化合物用于治疗各种炎症、心血管和免疫系统疾病的用途。此外，本发明提供了标记的3-取代-6-芳基吡啶，可用作C5a受体定位的探针。
• 3-Substituted-6-Aryl Pyridines
  申请人：Hutchison Alan J.

  公开号：US20090176980A1

  公开（公告）日：2009-07-09

  3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I中的3-取代-6-芳基吡啶化合物： 其中R1、R2、R3、R8、R9、A和Ar在此定义。这些化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及在治疗各种炎症，心血管和免疫系统疾病中使用这些化合物的用途。此外，本发明提供了标记的3-取代-6-芳基吡啶，可用作C5a受体的定位探针。
• CARBON COATED HEAT CONDUCTING MATERIAL
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP3213912A1

  公开（公告）日：2017-09-06

  The present invention provides a carbon-coated thermal conductive material which can improve water resistance, oxidation resistance, and dispersibility at the time of being kneaded with a resin while maintaining excellent thermal conductive performance. The present invention is a carbon-coated thermal conductive material having a coating layer composed of amorphous carbon on the surface of a thermal conductive material, in which the thermal conductive material is composed of a metal oxide, a metal nitride, a metal material, or a carbon-based material having a thermal conductivity of 10 W/mK or greater; the amorphous carbon is derived from carbon contained in an oxazine resin; in a case where the amorphous carbon is analyzed by Raman spectroscopy, a ratio of a peak intensity of a G band to a peak intensity of a D band is 1.0 or greater; an average film thickness of the coating layer is 500 nm or less; and a coefficient of variation (CV value) of a film thickness of the coating layer is 15% or less.

  本发明提供了一种碳涂层导热材料，该材料在与树脂捏合时可提高耐水性、抗氧化性和分散性，同时保持良好的导热性能。本发明是一种碳涂层导热材料，在导热材料表面有一层由无定形碳组成的涂层，其中导热材料由金属氧化物、金属氮化物、金属材料或导热系数大于等于 10 W/mK 的碳基材料组成；无定形碳来自恶嗪树脂中所含的碳；在用拉曼光谱分析无定形碳的情况下，G 波段的峰值强度与 D 波段的峰值强度之比为 1.0 或更大；涂层的平均膜厚为 500 nm 或更小；涂层膜厚的变异系数（CV 值）为 15%或更小。
• SHIRAI, NAOHIRO;SATO, YOSHIRO, J. ORG. CHEM., 53,(1988) N 1, 194-196
  作者：SHIRAI, NAOHIRO、SATO, YOSHIRO

  DOI：——

  日期：——
• THERAPEUTIC COMPOUNDS AND SYNTHESIS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3344628B9

  公开（公告）日：2021-06-30