N-phenylthiazole-5-carboxamide | 90842-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenylthiazole-5-carboxamide
• 英文别名: Thiazole-5-carboxanilide；N-phenyl-1,3-thiazole-5-carboxamide
• CAS: 90842-21-0
• 化学式: C₁₀H₈N₂OS
• mdl: MFCD08361437
• 分子量: 204.252
• InChiKey: KSWSCDXHZZVNAS-UHFFFAOYSA-N

物化性质

• 沸点：
  268.9±13.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  噻唑-5-甲酸 、 苯胺 在 三氯氧磷 作用下， 生成 N-phenylthiazole-5-carboxamide
  参考文献：
  名称：

  Lebedeva,I.V. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 2444 - 2448

  摘要：

  DOI：

文献信息

• [EN] N-PHENYLPYRAZOLE DERIVATIVES AS PESTICIDES<br/>[FR] DERIVES DE N-PHENYLPYRAZOLE UTILISES COMME PESTICIDES
  申请人：BAYER CROPSCIENCE SA

  公开号：WO2006000313A1

  公开（公告）日：2006-01-05

  The invention relates to bis-5-pyrazolyl derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

  这项发明涉及到式(I)的双-5-吡唑基衍生物或其盐：其中各种符号如描述中所定义，以及它们的制备方法、组合物，以及它们用于控制害虫（包括节肢动物和蠕虫）的用途。
• [EN] HEPATITIS B ANTIVIRAL AGENTS<br/>[FR] AGENTS ANTIVIRAUX DE L'HÉPATITE B
  申请人：ENANTA PHARM INC

  公开号：WO2017015451A1

  公开（公告）日：2017-01-26

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A1-Y-A2-Z-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明揭示了化合物的结构式（I），或其药用可接受的盐、酯或前药：X-A1-Y-A2-Z-L-R（I），这些化合物能够抑制由乙型肝炎病毒（HBV）编码的蛋白质，或干扰乙型肝炎病毒的生命周期功能，同时也可作为抗病毒药物使用。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HBV感染的受试者。该发明还涉及通过给受试者投予包含本发明化合物的药物组合物来治疗HBV感染的方法。
• INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Griffioen Gerard

  公开号：US20120083475A1

  公开（公告）日：2012-04-05

  This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

  该发明提供了新型化合物，以及这些新型化合物用作药物，特别是用于预防或治疗神经退行性疾病，更具体地说是某些神经系统疾病，例如被统称为tau病理学的疾病，以及由细胞毒性α-突触蛋白淀积所特征的疾病。本发明还涉及使用这些新型化合物制备治疗这种神经退行性疾病的药物。本发明还涉及包括这些新型化合物的制药组合物，以及制备这些新型化合物的方法。
• N-PHENYLPYRAZOLE DERIVATIVES AS PESTICIDES
  申请人：Merial Limited

  公开号：EP1761502A1

  公开（公告）日：2007-03-14
• BICYCLISCHE ENAMINO(THIO)CARBONYLVERBINDUNGEN
  申请人：Bayer CropScience AG

  公开号：EP2021344A1

  公开（公告）日：2009-02-11