4-Chlor-2-hydroxydiflubenzuron | 65980-67-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chlor-2-hydroxydiflubenzuron
• 英文别名: N-[(4-Chloro-2-hydroxyphenyl)carbamoyl]-2,6-difluorobenzamide
• CAS: 65980-67-8
• 化学式: C₁₄H₉ClF₂N₂O₃
• 分子量: 326.687
• InChiKey: LZYRIECPQGHNPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Benzoyl urea derivatives having anti-tumor activity
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0136745A2

  公开（公告）日：1985-04-10

  The invention relates to new benzoyl urea derivatives of the formula: lt has been found that these compounds have anti-tumor activity. The compounds of this formula in which at least one of the phenyl groups contains an optionally esterified hydroxy group have been found to possess the strongest activity. The new compounds can be prepared according to methods known for the synthesis of analogous compounds.

  本发明涉及式中新的苯甲酰脲衍生物： 发现这些化合物具有抗肿瘤活性。其中至少有一个苯基含有任选酯化的羟基，发现这种式的化合物具有最强的活性。 新化合物可以按照合成类似化合物的已知方法制备。
• Benzoyl urea derivatives having ati-tumor activity
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0193249A2

  公开（公告）日：1986-09-03

  The present invention relates to a group of new benzoyl urea derivatives of the formula having a better antitumor activity in comparison with known benzoyl urea derivatives. The compounds have been tested in several in vitro test models with different types of tumors.

  本发明涉及一组新的苯甲酰脲衍生物，其式为 与已知的苯甲酰脲衍生物相比，具有更好的抗肿瘤活性。这些化合物已在几种不同类型肿瘤的体外试验模型中进行了测试。