8-(hydroxymethyl)-2-methoxy-5',5'-dimethylspiro[5,7-dihydro-3H-pyrido[2,3-d]pyrimidine-6,2'-cyclohexane]-1',3',4-trione | 873576-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 8-(hydroxymethyl)-2-methoxy-5',5'-dimethylspiro[5,7-dihydro-3H-pyrido[2,3-d]pyrimidine-6,2'-cyclohexane]-1',3',4-trione
• CAS: 873576-86-4
• 化学式: C₁₆H₂₁N₃O₅
• 分子量: 335.36
• InChiKey: GREORIMKZMSXSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  8-(hydroxymethyl)-2-methoxy-5',5'-dimethylspiro[5,7-dihydro-3H-pyrido[2,3-d]pyrimidine-6,2'-cyclohexane]-1',3',4-trione 、 甲醇 反应 0.25h， 以70%的产率得到2-methoxy-8-(methoxymethyl)-5',5'-dimethylspiro[5,7-dihydro-3H-pyrido[2,3-d]pyrimidine-6,2'-cyclohexane]-1',3',4-trione
  参考文献：
  名称：

  Three-component synthesis of hexahydropyridopyrimidine–spirocyclohexanetriones induced by microwave

  摘要：

  Pyridopyrimidine-spirocyclohexanetriones (5, 6) and pyrimido[4,5-b]quinolinones (8) were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones (1) with dimedone (2) and formaldehyde solution or paraformaldehyde, respectively. A mechanism is proposed based on the presence of a basic catalyst (triethylamine in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.120
• 作为产物：
  描述：

  3-hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)methyl]-5,5-dimethylcyclohex-2-en-1-one 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 0.03h， 生成 8-(hydroxymethyl)-2-methoxy-5',5'-dimethylspiro[5,7-dihydro-3H-pyrido[2,3-d]pyrimidine-6,2'-cyclohexane]-1',3',4-trione
  参考文献：
  名称：

  Three-component synthesis of hexahydropyridopyrimidine–spirocyclohexanetriones induced by microwave

  摘要：

  Pyridopyrimidine-spirocyclohexanetriones (5, 6) and pyrimido[4,5-b]quinolinones (8) were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones (1) with dimedone (2) and formaldehyde solution or paraformaldehyde, respectively. A mechanism is proposed based on the presence of a basic catalyst (triethylamine in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.120

文献信息

• Three-component synthesis of hexahydropyridopyrimidine–spirocyclohexanetriones induced by microwave
  作者：Jairo Quiroga、Silvia Cruz、Braulio Insuasty、Rodrigo Abonía、Manuel Nogueras、Justo Cobo

  DOI：10.1016/j.tetlet.2005.10.120

  日期：2006.1

  Pyridopyrimidine-spirocyclohexanetriones (5, 6) and pyrimido[4,5-b]quinolinones (8) were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones (1) with dimedone (2) and formaldehyde solution or paraformaldehyde, respectively. A mechanism is proposed based on the presence of a basic catalyst (triethylamine in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products. (c) 2005 Elsevier Ltd. All rights reserved.