2,2'-[2-(4-diethylamino-phenyl)-imidazolidine-1,3-diyldimethyl]-bis-phenol | 65953-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2,2'-[2-(4-diethylamino-phenyl)-imidazolidine-1,3-diyldimethyl]-bis-phenol
• 英文别名: 1,3-Di-(o-hydroxy-benzyl)-2-(p-diethylamino-phenyl)-tetrahydroimidazol；1,3-Di(o-hydroxylbenzyl)-2-(p-diethylamino-phenyl)tetrahydroimidazole；2-[[2-[4-(diethylamino)phenyl]-3-[(2-hydroxyphenyl)methyl]imidazolidin-1-yl]methyl]phenol
• CAS: 65953-59-5
• 化学式: C₂₇H₃₃N₃O₂
• 分子量: 431.578
• InChiKey: PIBRXLXIMBOGJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N'-双(亚水杨基)乙二胺 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 2,2'-[2-(4-diethylamino-phenyl)-imidazolidine-1,3-diyldimethyl]-bis-phenol
  参考文献：
  名称：

  Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties

  摘要：

  Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01256-9

文献信息

• Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties
  作者：Vibha Sharma、M.S.Y Khan

  DOI：10.1016/s0223-5234(01)01256-9

  日期：2001.8

  Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli. (C) 2001 Editions scientifiques et medicales Elsevier SAS.