Methyl 3-[8-[4-(diethylamino)phenyl]-2,2-difluoro-12-(3-methoxy-3-oxopropyl)-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl]propanoate | 1313876-81-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methyl 3-[8-[4-(diethylamino)phenyl]-2,2-difluoro-12-(3-methoxy-3-oxopropyl)-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl]propanoate
• CAS: 1313876-81-1
• 化学式: C₂₇H₃₂BF₂N₃O₄
• 分子量: 511.377
• InChiKey: PITDGDQSHLLITI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.41
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  63.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N,N-二乙基-4-氨基苯甲醛 在 三氟化硼乙醚 、 四氯苯醌 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 25.5h， 生成 Methyl 3-[8-[4-(diethylamino)phenyl]-2,2-difluoro-12-(3-methoxy-3-oxopropyl)-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl]propanoate
  参考文献：
  名称：

  Selective labeling and monitoring pH changes of lysosomes in living cells with fluorogenic pH sensors

  摘要：

  New BODIPY-based pH probes have been designed with excitation and emission wavelengths suitable for fluorescence microscopy and flow cytometry. These pH probes are cell-permeable, selectively label lysosomes, and can be used for noninvasive monitoring of lysosomal pH changes during physiological and pathological processes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.137

文献信息

• Selective labeling and monitoring pH changes of lysosomes in living cells with fluorogenic pH sensors
  作者：Lai-Qiang Ying、Bruce P. Branchaud

  DOI：10.1016/j.bmcl.2011.04.137

  日期：2011.6

  New BODIPY-based pH probes have been designed with excitation and emission wavelengths suitable for fluorescence microscopy and flow cytometry. These pH probes are cell-permeable, selectively label lysosomes, and can be used for noninvasive monitoring of lysosomal pH changes during physiological and pathological processes. (C) 2011 Elsevier Ltd. All rights reserved.