1-Methyl-4-(2-hydroxyethyl)piperazine Benzoate | 81539-93-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methyl-4-(2-hydroxyethyl)piperazine Benzoate
• 英文别名: 2-(4-Methylpiperazin-1-yl)ethyl benzoate
• CAS: 81539-93-7
• 化学式: C₁₄H₂₀N₂O₂
• 分子量: 248.325
• InChiKey: VNRFHBJXUICWCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三乙烯二胺 、 苯甲酸甲酯 生成 1-Methyl-4-(2-hydroxyethyl)piperazine Benzoate
  参考文献：
  名称：

  Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts

  摘要：

  DOI：

  10.1007/bf00512969

文献信息

• Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
  申请人：NEUROSEARCH A/S

  公开号：US20040097570A1

  公开（公告）日：2004-05-20

  The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABA A receptor complex, and in particular for inducing and maintaining anesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.

  本发明涉及新型苯并咪唑衍生物，包含这些化合物的制药组合物，以及使用它们的治疗方法。该发明的化合物在治疗对GABAA受体复合物调节有响应的中枢神经系统疾病和疾病方面具有用途，特别是用于诱导和维持麻醉、镇静和肌肉松弛，以及对儿童的热性惊厥进行抗击。该发明的化合物也可以被兽医使用。
• VYSOCHIN, V. I.;SHISHKIN, G. V., XIMIYA GETEROTSIKL. SOEDIN., 1982, N 2, 250-255
  作者：VYSOCHIN, V. I.、SHISHKIN, G. V.

  DOI：——

  日期：——
• [EN] NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS<br/>[FR] NOUVEAUX DERIVES DE BENZIMIDAZOLE ET COMPOSITIONS PHARMACEUTIQUES COMPRENANT CES COMPOSES
  申请人：NEUROSEARCH AS

  公开号：WO2000078728A1

  公开（公告）日：2000-12-28

  The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anaesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.
• Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts
  作者：V. I. Vysochin、G. V. Shishkin

  DOI：10.1007/bf00512969

  日期：1982.2