2-甲氧基-N-N-丙基去甲阿朴吗啡 | 126874-82-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 中文名称: 2-甲氧基-N-N-丙基去甲阿朴吗啡
• 英文名称: 2-Methoxy-N-n-propylnorapomorphine
• 英文别名: (6aR)-2-methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
• CAS: 126874-82-6
• 化学式: C₂₀H₂₃NO₃
• 分子量: 325.4
• InChiKey: WNNMRMNAGNMVEW-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE 2-ALCOXY-11-HYDROXYAPORPHINE ET LEURS UTILISATIONS
  申请人：MCLEAN HOSPITAL CORP

  公开号：WO2011130530A1

  公开（公告）日：2011-10-20

  The invention features 2-alkoxy-l l-hydroxyaporphine derivatives that selectively bind D2high receptors. The compounds are useful for imaging D2high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.

  这项发明涉及选择性结合D2高亲和力受体的2-烷氧基-1-羟基吖啶衍生物。这些化合物可用于成像D2高亲和力受体以及用于治疗帕金森病、性功能障碍和抑郁症等疾病。
• 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF
  申请人：The McLean Hospital Corporation

  公开号：US20170166531A1

  公开（公告）日：2017-06-15

  The invention features 2-alkoxy-11-hydroxyaporphine derivatives that selectively bind D 2 high receptors. The compounds are useful for imaging D 2 high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.