2-(morpholin-4-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate | 1432740-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(morpholin-4-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate
• 英文别名: 2-morpholin-4-ylethyl N-(2,6-dichloropyridin-4-yl)carbamate
• CAS: 1432740-81-2
• 化学式: C₁₂H₁₅Cl₂N₃O₃
• 分子量: 320.175
• InChiKey: MYFMXGCAQYZCTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-吗啉乙醇 、 4-氨基-2,6-二氯吡啶 、 三光气 在 三乙胺 作用下， 以 苯 为溶剂， 反应 5.0h， 以70%的产率得到2-(morpholin-4-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate
  参考文献：
  名称：

  New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

  摘要：

  The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.

  DOI：

  10.1021/ml400039r

文献信息

• New Promising Compounds with in Vitro Nanomolar Activity against <i>Trypanosoma cruzi</i>
  作者：Laura Friggeri、Luigi Scipione、Roberta Costi、Marcel Kaiser、Francesca Moraca、Claudio Zamperini、Bruno Botta、Roberto Di Santo、Daniela De Vita、Reto Brun、Silvano Tortorella

  DOI：10.1021/ml400039r

  日期：2013.6.13

  The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.