3-(3-{[(4-Chloro-2-fluorobenzoyl)amino]-methyl}-4-propoxyphenyl)-5-fluorobenzoic acid | 478372-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-{[(4-Chloro-2-fluorobenzoyl)amino]-methyl}-4-propoxyphenyl)-5-fluorobenzoic acid
• 英文别名: 3-[3-[[(4-Chloro-2-fluorobenzoyl)amino]methyl]-4-propoxyphenyl]-5-fluorobenzoic acid
• CAS: 478372-42-8
• 化学式: C₂₄H₂₀ClF₂NO₄
• 分子量: 459.877
• InChiKey: FIGRMFODDSOUCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-氯-2-氟苯甲酸 生成 3-(3-{[(4-Chloro-2-fluorobenzoyl)amino]-methyl}-4-propoxyphenyl)-5-fluorobenzoic acid
  参考文献：
  名称：

  EP1394147

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING COMPOUND, COMPOUND, EPOXY CURING AGENT, AND METHOD FOR PRODUCING AMINE COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20210198181A1

  公开（公告）日：2021-07-01

  Provided are: a method for producing a compound that excels in storage stability and handleability; the compound; and an epoxy curing agent containing the compound. The method for producing a compound represented by Formula (1-1) includes subjecting the compound represented by Formula (5-1) to an addition reaction to add ethylene and/or propylene in the presence of a base. In Formula (5-1), R X to R Z each independently represent a hydrogen atom, an ethyl group, an n-propyl group, or an isopropyl group, and n is an integer of from 1 to 3. In Formula (1-1), R A to R D each independently represent a hydrogen atom, an ethyl group, an n-propyl group, or an isopropyl group, and n is an integer of from 1 to 3.

  提供了一种生产在储存稳定性和操控性方面表现优异的化合物的方法；该化合物；以及包含该化合物的环氧固化剂。表示为Formula（1-1）的化合物的生产方法包括在碱存在下，使表示为Formula（5-1）的化合物经历加成反应以添加乙烯和/或丙烯。在Formula（5-1）中，RX到RZ分别独立表示氢原子、乙基基团、正丙基基团或异丙基基团，n为1至3之间的整数。在Formula（1-1）中，RA到RD分别独立表示氢原子、乙基基团、正丙基基团或异丙基基团，n为1至3之间的整数。
• METALLOTRIANGLE-BASED NANOMOLECULES AND METHODS OF MAKING THE SAME
  申请人：Newkome George R.

  公开号：US20160214938A1

  公开（公告）日：2016-07-28

  Metallotriangle-based nanomolecules are formed by a one-step self-assembly of specifically chosen shaped poly-ligand monomers, the poly-ligand monomers coordinating with metal ions through coordinating ligands. The poly-ligand monomers are defined by vertex groups having arms extending therefrom and ending in coordinating ligands. Based on the desired metallotriangle-based nanomolecule structure to be assembled, specifically shaped poly-ligand monomers and metal ions are chosen and mixed in appropriate ratios so that coordinating ligands bind to metal ions and the poly-ligand monomers thus spontaneously self-assemble into the desired metallotriangle-based nanomolecule structure.

  金属三角形纳米分子是通过一步自组装形成的，具体选择形状的多配体单体通过配位配体与金属离子配位。多配体单体由顶点群定义，其具有向外延伸并以协同配体结束的臂。根据所需的金属三角形纳米分子结构进行组装，选择特定形状的多配体单体和金属离子，并以适当的比例混合，使协同配体与金属离子结合，从而使多配体单体自发地自组装成所需的金属三角形纳米分子结构。
• Aromatic diamine derivatives, the preparation thereof and alignment film materials containing same for liquid crystal display cell
  申请人：——

  公开号：US20040084653A1

  公开（公告）日：2004-05-06

  New aromatic diamine derivatives and the preparation thereof are disclosed. The diamine derivatives of the present invention can be added to conventional polymerization reactions of tetracarboxylic acids or dianhydrides thereof and diamines to form new polyamic acids. After high-temperature baking, the polyamic acids are cyclized to form polyimides. These polyimides can be used as alignment film materials for liquid crystal display cell and have good alignment property and stability, and are effective in promoting pre-tilt angles.

  本发明揭示了一种新的芳香族二胺衍生物及其制备方法。本发明的二胺衍生物可添加到四羧酸或其二酐和二胺的传统聚合反应中，形成新的聚酰亚胺酸。经过高温烘烤后，聚酰亚胺酸被环化成为聚酰亚胺。这些聚酰亚胺可用作液晶显示器单元的对准膜材料，具有良好的对准性能和稳定性，并且能有效促进预倾斜角。
• Carboxylic acid derivative and medicine comprising salt or ester of the same
  申请人：——

  公开号：US20040214888A1

  公开（公告）日：2004-10-28

  The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula: 1 (wherein L represents a single bond, or a C1 to C6 alkylene group, a C2 to C6 alkenylene group or a C2 to C6 alkynylene group, each of which may have one or more substituent groups; M represents a single bond, or a C1 to C6 alkylene group, a C2 to C6 alkenylene group or a C2 to C6 alkynylene group, each of which may have one or more substituent groups; T represents a single bond, or a C1 to C3 alkylene group, a C2 to C3 alkenylene group or a C2 to C3 alkynylene group, each of which may have one or more substituent groups; W represents a carboxyl group; X represents a single bond, an oxygen atom, or a group represented by the various substituent groups including —NR X1 CQ 1 O— (wherein Q 1 represents an oxygen atom or a sulfur atom; R X1 represents a hydrogen atom, a cyano group, a formyl group, or various groups including a C1 to C6 alkyl group and a C1 to C6 hydroxyalkyl group, each of which may have one or more substituent groups), ONR X1 CQ 1 —, —NR X1 CQ 1 —, —CQ 1 NR X1 —, —NR X1a CQ 1 NR X1b —, —Q 2 SO 2 — and —SO 2 Q 2 —; Y represents a 5 to 14-membered aromatic group which may have one or more substituent groups and one or more hetero atoms, or a C3 to C7 alicyclic hydrocarbon group; and the rings Z and U may be the same as or different from each other and each represents a 5 to 14-membered aromatic group which may have 1 to 4 substituent groups and one or more hetero atoms, and the ring may be partially saturated.), a salt thereof, an ester thereof or a hydrate of them.

  本发明提供了一种新型羧酸衍生物，可用作胰岛素增敏剂，其盐或其水合物，以及包含该衍生物作为活性成分的药物。具体而言，本发明提供了一种由以下式子表示的羧酸衍生物：1（其中L表示单键，或C1至C6烷基，C2至C6烯基或C2至C6炔基，每个基团都可以有一个或多个取代基；M表示单键，或C1至C6烷基，C2至C6烯基或C2至C6炔基，每个基团都可以有一个或多个取代基；T表示单键，或C1至C3烷基，C2至C3烯基或C2至C3炔基，每个基团都可以有一个或多个取代基；W表示羧基；X表示单键，氧原子，或由各种取代基表示的基团，包括-NRX1CQ1O-（其中Q1表示氧原子或硫原子；RX1表示氢原子，氰基，甲酰基或各种基团，包括C1至C6烷基和C1至C6羟基烷基，每个基团都可以有一个或多个取代基），ONRX1CQ1-，-NRX1CQ1-，-CQ1NRX1-，-NRX1aCQ1NRX1b-，-Q2SO2-和-SO2Q2-；Y表示一个具有1个或多个取代基和1个或多个杂原子的5至14环芳基，或一个C3至C7脂环烃基；环Z和环U可以相同或不同，每个环表示一个具有1至4个取代基和1个或多个杂原子的5至14环芳基，环可能部分饱和），其盐，酯或其水合物。
• Aromatic diamine derivatives, the preparations thereof, and alignment film materials containing same for liquid crystal display cell
  申请人：——

  公开号：US20040102603A1

  公开（公告）日：2004-05-27

  New aromatic diamine derivatives and the preparations thereof are disclosed. The inventive diamine derivatives can be added to conventional polymerization reactions of tetracarboxylic acids and diamines to form new polyamic acids. After high-temperature baking, the polyamic acids are cyclized to form polyimides. These polyimides can be used as alignment film materials for liquid crystal display cell and have good alignment property and stability, and are effective in promoting pre-tilt angle.

  本发明公开了新的芳香族二胺衍生物及其制备方法。这些创新的二胺衍生物可以添加到传统的四羧酸和二胺聚合反应中，形成新的聚酰亚胺酸。高温烘烤后，这些聚酰亚胺酸可以环化成为聚酰亚胺。这些聚酰亚胺可以用作液晶显示器单元的取向膜材料，具有良好的取向性和稳定性，并且能够有效促进预倾斜角度。