3-chloro-N-(2-nitrophenyl)benzenamine | 33490-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-N-(2-nitrophenyl)benzenamine
• 英文别名: 3-chloro-N-(2-nitrophenyl)benzamide；N-(m-Chlorbenzoyl)-o-nitroanilin
• CAS: 33490-00-5
• 化学式: C₁₃H₉ClN₂O₃
• 分子量: 276.679
• InChiKey: KBUNUZDDYHWMKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间氯苯甲酰胺 、 potassium o-nitrobenzoate 在 silver(I) carbonate 、 copper(II) sulfate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 12.0h， 以79%的产率得到3-chloro-N-(2-nitrophenyl)benzenamine
  参考文献：
  名称：

  CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acids with amides and anilines

  摘要：

  CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with aromatic carboxylic acids to give diarylamines in good to excellent yields. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2014.12.085

文献信息

• Transition-metal-free mono- or dinitration of protected anilines
  作者：Enrui Dai、Yongrui Dong、Rui Kong、Guangzhang Liu、Ying Dong、Qiong Wu、Deqiang Liang、Yinhai Ma

  DOI：10.1080/00397911.2020.1752730

  日期：2020.6.2

  Abstract An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity. Graphical Abstract

  摘要 提出了酰胺辅助芳烃硝化，分别使用NaNO2和NaNO3作为单硝化剂和双硝化剂，可以实现受保护苯胺的单硝化和二硝化。这种发散合成不含过渡金属和酸，具有广泛的底物范围、低成本和邻位选择性。图形概要
• PHARMACEUTICAL COMPOSITION AND METHOD
  申请人：Slade Rachel M.

  公开号：US20090155903A1

  公开（公告）日：2009-06-18

  The invention provides compounds, pharmaceutical compositions and methods for the therapeutic treatment and prevention of neurodegenerative disorder and other Aβ 42 -related diseases and disorders.

  该发明提供了化合物、制药组合物和方法，用于治疗和预防神经退行性疾病和其他与Aβ42相关的疾病和障碍。
• CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acids with amides and anilines
  作者：Wei-Jian Sheng、Qing Ye、Wu-Bin Yu、Ren-Rong Liu、Meng Xu、Jian-Rong Gao、Yi-Xia Jia

  DOI：10.1016/j.tetlet.2014.12.085

  日期：2015.1

  CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with aromatic carboxylic acids to give diarylamines in good to excellent yields. (C) 2014 Published by Elsevier Ltd.