N-[(2'-aminonaphthalen-1-yl)(4-nitrophenyl)methyl]acetamide | 1411585-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2'-aminonaphthalen-1-yl)(4-nitrophenyl)methyl]acetamide
• 英文别名: N-[(2-aminonaphthalen-1-yl)-(4-nitrophenyl)methyl]acetamide
• CAS: 1411585-44-8
• 化学式: C₁₉H₁₇N₃O₃
• 分子量: 335.362
• InChiKey: VSMLHIMMUKDXBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酰胺 、 对硝基苯甲醛 、 2-萘胺 在 silica chloride 作用下， 以 水 为溶剂， 反应 0.2h， 以97%的产率得到N-[(2'-aminonaphthalen-1-yl)(4-nitrophenyl)methyl]acetamide
  参考文献：
  名称：

  Silica chloride catalyzed efficient route to novel 1-amidoalkyl-2-naphthylamines under sonic condition in water

  摘要：

  A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.06.008

文献信息

• Silica chloride catalyzed efficient route to novel 1-amidoalkyl-2-naphthylamines under sonic condition in water
  作者：Bandita Datta、M.A. Pasha

  DOI：10.1016/j.ultsonch.2012.06.008

  日期：2013.1

  A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents. (c) 2012 Elsevier B.V. All rights reserved.