Progesteron-20-(O-carboxymethyl)-oxim | 10190-94-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Progesteron-20-(O-carboxymethyl)-oxim
• 英文别名: 2-[1-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]ethylideneamino]oxyacetic acid
• CAS: 10190-94-0
• 化学式: C₂₃H₃₃NO₄
• 分子量: 387.519
• InChiKey: TVMPNJIDKYPVIZ-CSPZMSETSA-N

物化性质

• 沸点：
  546.6±60.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  76
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  pregnenolone 20-<(methoxycarbonyl)methyl>oxime 在 chromium(VI) oxide 、 氢氧化钾 、 sodium hydroxide 、 硫酸 作用下， 以 甲醇 、 乙醇 、 丙酮 为溶剂， 反应 0.25h， 生成 Progesteron-20-(O-carboxymethyl)-oxim
  参考文献：
  名称：

  Zorina, A. D.; Martynov, V. F.; Matyukhina, L. G., Journal of general chemistry of the USSR, 1980, vol. 50, p. 156 - 157

  摘要：

  DOI：

文献信息

• The use of homologous and hetebologous 125 I-radioligands in the radioimmunoassay of progesterone
  作者：R Allen

  DOI：10.1016/0039-128x(78)90059-4

  日期：1978.11

  Eight homologous and heterologous 125I-radioligand systems for the radioimmunoassay of progesterone were examined. Using an antiserum raised to 11alpha-hydroxyprogesterone 11-succinyl-bovine serum albumin, standard curves were set up with the homologous radioligands, 11alpha-hydroxyprogesterone 11-succinyl-[125I]-iodotyramine, -[125I]-iodohistamine and -[125I]-iodotyrosine methyl ester. Heterologous bridge systems were represented by progesterone-11alpha-oxycarbonyl-[125I]-iodotyrosine methyl ester and 11alpha-hydroxyprogesterone 11-phthalyl-[125I]-iodotyrosine methyl ester, and heterologous site systems by progesterone-3-(O-carboxymethyl)oxime-[125I]-iodotyramine, progesterone-12-(O-carboxymethyl)oxime-[125I]-iodotyramine, and progesterone-20-(O-carboxymethyl)oxime-[125I]-iodohistamine. The preparation of the steroid derivatives and iodination by a two-phase method are described. The curves obtained from the homologous radioligands were relatively insensitive compared with a tritiated system, with the tyrosine methyl ester derivative providing a more sensitive assay than the corresponding tyramine or histamine analogues. The heterologous bridge systems gave more sensitive curves than the homologous tracers whilst the 3- and 12-(O-carboxymethyl)oxime derivatives of progesterone furnished curves as sensitive as the tritiated reference. Progesterone-20-(O-carboxymethyl)oxime-[125I]-iodohistamine was not bound by the antibody.
• Erlanger et al., Journal of Biological Chemistry, 1959, vol. 234, p. 1090,1093
  作者：Erlanger et al.

  DOI：——

  日期：——
• Zorina, A. D.; Martynov, V. F.; Matyukhina, L. G., Journal of general chemistry of the USSR, 1980, vol. 50, p. 156 - 157
  作者：Zorina, A. D.、Martynov, V. F.、Matyukhina, L. G.、Saltykova, I. A.

  DOI：——

  日期：——