1-(4-hydroxybenzoyl)-4-isopropylpiperazine | 90210-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-hydroxybenzoyl)-4-isopropylpiperazine
• 英文别名: (4-hydroxy-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone；Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-；(4-hydroxyphenyl)-(4-propan-2-ylpiperazin-1-yl)methanone
• CAS: 90210-23-4
• 化学式: C₁₄H₂₀N₂O₂
• mdl: MFCD06741433
• 分子量: 248.325
• InChiKey: ILKHFVMVAPOCMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-hydroxybenzoyl)-4-isopropylpiperazine 生成 [4-(4-propan-2-ylpiperazine-1-carbonyl)phenyl] 2-(5-methoxy-1,2-dimethylindol-3-yl)acetate;hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  1-异丙基哌嗪 在 草酰氯 、 potassium carbonate 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 1-(4-hydroxybenzoyl)-4-isopropylpiperazine
  参考文献：
  名称：

  Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

  摘要：

  Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 mu M.

  DOI：

  10.1016/s0223-5234(97)89852-2

文献信息

• Benzoylpiperazine esters and a process for their production
  申请人：Kowa Co., Ltd.

  公开号：US04898876A1

  公开（公告）日：1990-02-06

  A benzopylpiperazine ester of the following formula: ##STR1## wherein A represents a single bond or an alkylene group, vinylene group, --O--alkylene group or methine group, R.sub.1 represents a bicyclic carbon ring residue which may be substituted with a lower alkyl group, lower alkoxy group, oxo group or nitro group or a halogen atom, or may be partially saturated; a fluorene residue which may contain an oxo group; a fluorenylidene group; an anthracene residue; a phenanthrene residue which may be substituted with a lower alkyl group, or may be partially saturated; a benzofuran residue or thianaphthene residue which may be substituted with a lower alkyl group or lower alkoxy group; a benzopyran residue or benzoazine residue which may be substituted with an oxo group or phenyl group and partially saturated; a phthalimide residue; a benzodiazine residue; an isozazole residue which may be substituted with a lower alkyl group or phenyl group; or an alkylene dioxybenzene residue or xanthene residue; and R.sub.2 represents an alkyl group, cycloalkyl group, cycloalkylalkyl group or aralkyl group, excepting the case where A is a single bond, R.sub.1 is ##STR2## and R.sub.2 is a methyl group, exhibits excellent chymotrypsin inhibitive activity.

  下列化合物的苯并哌嗪酯化物式：##STR1## 其中，A代表单键或烷基、乙烯基、--O--烷基或甲基基团，R.sub.1代表一个双环碳环残基，可以被低烷基、低氧基、氧代基或硝基或卤素原子取代，或者部分饱和；一个含氧代基的芴环残基；一个芴亚甲基基团；一个蒽环残基；一个苯并并芘环残基，可以被低烷基取代，或者部分饱和；一个苯并呋喃环残基或噻萘环残基，可以被低烷基或低氧基取代；一个苯并吡喃环残基或苯并嗪环残基，可以被氧代基或苯基取代并部分饱和；一个邻苯二甲酰亚胺残基；一个苯并二氮杂环残基；一个噻唑杂环残基，可以被低烷基或苯基取代；或者一个烷基双氧基苯环残基或黄色素环残基；R.sub.2代表烷基、环烷基、环烷基烷基或芳基烷基，除非A是单键，R.sub.1是##STR2##，R.sub.2是甲基基团，否则展现出出色的胰蛋白酶抑制活性。
• SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS
  申请人：Keith John M.

  公开号：US20080139564A1

  公开（公告）日：2008-06-12

  Certain substituted phenyl propyl amine compounds are histamine H 3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H 3 receptor- and/or serotonin-mediated diseases.

  某些取代苯基丙胺化合物是组胺H3受体和/或血清素转运体调节剂，可用于治疗组胺H3受体和/或血清素介导的疾病。
• Benzoyl indolecarboxylates
  申请人：Kowa Co., Ltd.

  公开号：US04605739A1

  公开（公告）日：1986-08-12

  Benzoyl indolecarboxylates of the formula: ##STR1## where R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy; R.sup.2 is hydrogen, lower alkyl, acetyl or benzoyl; R.sup.3 is hydrogen or lower alkyl; and A is a direct bond, or lower alkylene or vinylene substituted at the 2-, 3- or 5-position of the indole nucleus, are effective agents as chymotrypsin inhibitors.

  公式为：##STR1## 的苯甲酰吲哚羧酸酯是有效的凝血酶抑制剂，其中R.sup.1为氢、卤素、低碳基或低氧基；R.sup.2为氢、低碳基、乙酰基或苯甲酰基；R.sup.3为氢或低碳基；A为直接键，或在吲哚环的2-、3-或5-位取代低碳基或乙烯基。
• Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin
  作者：P Zlatoidský、T Maliar

  DOI：10.1016/0223-5234(96)85875-2

  日期：1996.1

  Sixteen new esters and amides of 4-acyloxybenzoic acids were prepared and screened as chymotrypsin inhibitors. Inhibiting activities on chymotrypsin differed markedly (> 100-0.008 mu M). Compounds which contained the 4-benzoyloxyacetyl moiety showed considerably higher activity then 4-acyloxybenzamides. Compounds 1c and 11f are also weak trypsin inhibitors.
• FUDZII, SEHTSURO;XATTORI, EHJDZO;XIRATA, MITSUTEHRU;VATANABEH, KOITIRO;ON+
  作者：FUDZII, SEHTSURO、XATTORI, EHJDZO、XIRATA, MITSUTEHRU、VATANABEH, KOITIRO、ON+

  DOI：——

  日期：——