1-oxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydronaphthalene | 41552-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-oxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydronaphthalene
• 英文别名: 5-Hydroxy-6-methyl-3,4-dihydronaphthalen-1(2H)-one；5-hydroxy-6-methyl-3,4-dihydro-2H-naphthalen-1-one
• CAS: 41552-07-2
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: NDLFNSWXWAFJSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319

反应信息

• 作为反应物：
  描述：

  1-oxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydronaphthalene 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 29.0h， 生成 2,5-二甲基萘-1-醇
  参考文献：
  名称：

  Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids

  摘要：

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.

  DOI：

  10.1023/b:rugc.0000018662.02489.8d
• 作为产物：
  描述：

  1,5-二羟基-1,2,3,4-四氢萘 在 palladium on activated charcoal 三氯化铝 、 jones reagent 作用下， 以 乙醚 、 乙醇 、 丙酮 为溶剂， 反应 28.75h， 生成 1-oxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids

  摘要：

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.

  DOI：

  10.1023/b:rugc.0000018662.02489.8d

文献信息

• Derivatives of 3,4-dihydro-1(2H)-naphthalenone as .beta.-adrenergic blocking agents. 2. Aromatic-substituted analogs of bunolol
  作者：Charles F. Schwender、Russell E. Pike、John Shavel

  DOI：10.1021/jm00261a020

  日期：1973.3
• Synthesis of Some Substituted Naphthalenes as Potential Intermediates for Polyethers and Terpenoids
  作者：A. K. Banerjee、P. S. Poon、M. S. Laya、J. A. Azocar

  DOI：10.1023/b:rugc.0000018662.02489.8d

  日期：2003.11

  1-Benzyloxy-5-hydroxynaphthalene and 1,6-dimethyl-5-hydroxynaphthalene were prepared from 5-methoxy-alpha-tetralone. 6-Methoxy-alpha-tetralone was converted to 1,6-dimethoxy-2-isopropylnaphthalene.