[1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid | 798543-81-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid
• 英文别名: 2-[1-[(2,4-dimethoxyphenyl)methyl]-6-oxo-2,3-dihydropyridin-5-yl]acetic acid
• CAS: 798543-81-4
• 化学式: C₁₆H₁₉NO₅
• 分子量: 305.331
• InChiKey: PSGIGBBFVVNXMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  [1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3 yl]-acetic acid methyl ester 在 lithium hydroxide 作用下， 生成 [1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid
  参考文献：
  名称：

  [EN] NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
  [FR] NOUVEAUX COMPOSES 2-OXO-HETEROCYCLIQUES ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES

  摘要：

  本发明涉及新的2-氧代环化合物及其制备方法和包含其的药物组合物。本发明提供了一种用于预防和治疗炎症性疾病的药物组合物，包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎、脊柱关节病、痛风、骨关节炎、全身性红斑狼疮和儿童关节炎，以及炎症综合征，例如肌炎、牙龈炎、滑囊炎、强直性脊柱炎、滑囊炎、烧伤和疤痕、炎症性克罗恩病、I型糖尿病等。因此，它可以用作治疗和预防炎症性疾病的治疗药物。

  公开号：

  WO2004101523A1

文献信息

• Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
  申请人：Han Hee Gyoon

  公开号：US20060173043A1

  公开（公告）日：2006-08-03

  The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

  本发明涉及具有抗癌活性的2-氧代杂环化合物的新用途及其制备过程，以及包含它们的药物组合物。本发明提供了一种用于预防和治疗肺癌、骨癌、胰腺癌、皮肤癌、头颈部癌症、皮肤或眼内黑色素瘤、子宫癌、卵巢癌、直肠癌或肛门区癌症、胃癌、结肠癌、乳腺癌、妇科肿瘤、霍奇金病、食管癌、小肠癌、内分泌系统癌症、软组织肉瘤、尿道癌、阴茎癌、前列腺癌、慢性或急性白血病、儿童实体瘤、淋巴细胞性淋巴瘤、膀胱癌、肾或输尿管癌或中枢神经系统肿瘤的药物组合物，因此，它可以用作治疗和预防癌症疾病的治疗药物。
• Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
  申请人：Kho Hee Yung

  公开号：US20070167486A1

  公开（公告）日：2007-07-19

  The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

  本发明涉及新的2-氧代环状化合物及其制备方法和包含它们的药物组合物。本发明提供了一种用于预防和治疗炎症性疾病的药物组合物，包括由风湿性疾病引起的疼痛或炎症，例如风湿性关节炎、脊柱关节病、痛风、骨关节炎、全身性红斑狼疮和儿童关节炎，以及炎症综合征，例如肌炎、牙龈炎、滑膜炎、强直性脊柱炎、滑囊炎、烧伤和疤痕、炎性克罗恩病、1型糖尿病等。因此，它可以用作治疗和预防炎症性疾病的治疗剂。
• 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：US07846963B2

  公开（公告）日：2010-12-07

  The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

  本发明涉及新的2-氧代环状化合物，其制备方法以及包含它们的药物组合物。本发明提供了一种用于预防和治疗炎症性疾病的药物组合物，包括由风湿性疾病引起的疼痛或炎症，例如风湿性关节炎、脊柱关节病、痛风、骨关节炎、系统性红斑狼疮和青少年关节炎，以及由肌炎、牙龈炎、滑膜炎、强直性脊柱炎、滑囊炎、烧伤和疤痕、炎症性克罗恩病、1型糖尿病等引起的炎症综合征。因此，它可以用作治疗和预防炎症性疾病的治疗药物。
• Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same
  申请人：KHO Yung Hee

  公开号：US20100286207A1

  公开（公告）日：2010-11-11

  The present invention is related to new 2-oxo-cyclic compound, the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

  本发明涉及一种新的2-氧代环状化合物、其制备方法以及包含其的药物组合物。本发明提供了一种预防和治疗炎症性疾病的药物组合物，包括由风湿性疾病引起的疼痛或炎症，例如风湿性关节炎、脊柱关节病、痛风、骨关节炎、系统性红斑狼疮和少年关节炎，以及由肌炎、牙龈炎、滑膜炎、强直性脊柱炎、滑囊炎、烧伤和瘢痕、炎症性克罗恩病、1型糖尿病等引起的炎症综合征。因此，它可以用作治疗和预防炎症性疾病的治疗药物。
• 2-oxo-heterocyclic compounds and pharmaceutical compositions
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：US07723376B2

  公开（公告）日：2010-05-25

  The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

  本发明涉及具有抗癌活性的2-氧代杂环化合物的新用途及其制备过程，以及包含它们的药物组合物。本发明提供了一种用于预防和治疗肺癌、骨癌、胰腺癌、皮肤癌、头颈部癌症、皮肤或眼内黑色素瘤、子宫癌、卵巢癌、直肠癌或肛门癌、胃癌、结肠癌、乳腺癌、妇科肿瘤、霍奇金病、食管癌、小肠癌、内分泌系统癌症、软组织肉瘤、尿道癌、阴茎癌、前列腺癌、慢性或急性白血病、儿童实体瘤、淋巴细胞淋巴瘤、膀胱癌、肾或输尿管癌或中枢神经系统肿瘤的肿瘤疾病的药物组合物，因此，它可以作为治疗和预防癌症疾病的治疗剂。