7-acetamido-4-benzyl-1-methyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 499783-76-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-acetamido-4-benzyl-1-methyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
• 英文别名: N-(4-benzyl-1-methyl-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-7-yl)acetamide
• CAS: 499783-76-5
• 化学式: C₁₉H₁₇N₅O₂
• 分子量: 347.376
• InChiKey: QWAQCAVRSXNHSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环戊基甲酰氯 、 6-acetamido-3-benzyl-2-hydrazino-3,4-dihydro-quinazolin-4-one 以 溶剂黄146 为溶剂， 反应 0.33h， 生成 7-acetamido-4-benzyl-1-methyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
  参考文献：
  名称：

  1-alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors

  摘要：

  本发明涉及式(I)的化合物，其中R1、R2和R3如描述中所定义，它们作为药物的用途，其制备过程以及它们用于治疗需要PDE4抑制剂治疗的病理情况的用途。

  公开号：

  US20030069260A1

文献信息

• 1-alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
  申请人：Warner-Lambert LLC

  公开号：US06747035B2

  公开（公告）日：2004-06-08

  The invention relates to compounds of formula (I), in which R1, R2 and R3 are as defined in the description, their use as medicaments, the process for their preparation and their use for the treatment of pathologies in which therapy by a PDE4 inhibitor is relevant.

  该发明涉及式(I)的化合物，其中R1、R2和R3如描述中所定义，它们作为药物的用途，它们的制备过程以及它们用于治疗需要PDE4抑制剂治疗的病理情况的用途。
• 1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1285922A1

  公开（公告）日：2003-02-26

  The invention relates to compounds of formula (I), in which R1, R2 and R3 are as defined in the description, their use as medicaments, the process for their preparation and their use for the treatment of pathologies in which therapy by a PDE4 inhibitor is relevant.

  本发明涉及式（I）化合物、 中 R1、R2 和 R3 的定义、它们作为药物的用途、它们的制备过程以及它们用于治疗与 PDE4 抑制剂治疗相关的病症的用途。
• 1-ALKYL 0R 1-CYCLOALKYLTRIAZOLO 4,3-A]QUINAZOLIN-5-ONES AS PHOSPHODIESTERASE INHIBITORS
  申请人：Warner-Lambert Company LLC

  公开号：EP1419159A1

  公开（公告）日：2004-05-19
• US6747035B2
  申请人：——

  公开号：US6747035B2

  公开（公告）日：2004-06-08
• [EN] 1-ALKYL 0R 1-CYCLOALKYLTRIAZOLO[4,3-A]QUINAZOLIN-5-ONES AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] 1-ALKYLE 0U 1-CYCLOALKYLTRIAZOLO[4,3-A]QUINAZOLIN-5-ONES UTILISEES COMME INHIBITEURS DE LA PHOSPHODIESTERASE
  申请人：WARNER LAMBERT CO

  公开号：WO2003016314A1

  公开（公告）日：2003-02-27

  The invention relates to compounds of formula (I), in which R?1, R2 and R3¿ are as defined in the description, their use as medicaments, the process for their preparation and their use for the treatment of pathologies in which therapy by a PDE4 inhibitor is relevant.