N-[2-(4,4'-difluoro-benzhydryloxy)-ethyl]-phthalimide | 50499-52-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(4,4'-difluoro-benzhydryloxy)-ethyl]-phthalimide
• 英文别名: N-{2-[bis(p-fluorophenyl)methoxy]-ethyl}phthalimide；2-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-1H-isoindole-1,3(2H)-dione；2-[2-[bis(4-fluorophenyl)methoxy]ethyl]isoindole-1,3-dione
• CAS: 50499-52-0
• 化学式: C₂₃H₁₇F₂NO₃
• 分子量: 393.39
• InChiKey: GNCZQCDZYIDIAV-UHFFFAOYSA-N

物化性质

• 沸点：
  503.9±50.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[2-(4,4'-difluoro-benzhydryloxy)-ethyl]-phthalimide 在 盐酸肼 作用下， 以 乙醇 、 水 为溶剂， 生成 双氟苯乙胺
  参考文献：
  名称：

  New prenylamine analogues: synthesis and Ca2+-entry blocking activity

  摘要：

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.

  DOI：

  10.1016/0223-5234(92)90136-o
• 作为产物：
  描述：

  2-[bis(4-fluorophenyl)methoxy]ethyl chloride 、 potassium phtalimide 以 N-甲基乙酰胺 、 水 为溶剂， 生成 N-[2-(4,4'-difluoro-benzhydryloxy)-ethyl]-phthalimide
  参考文献：
  名称：

  Aminoalkylethers

  摘要：

  一般式为##STR1##的二苯甲氧基乙胺，其中R.sub.1代表氟、溴或氯原子，R.sub.2代表氢或氟原子，R.sub.3代表氢、氟或氯原子，但有以下限制条件：当R.sub.2为氟原子时，R.sub.3为氢原子；当R.sub.3为氯原子时，R.sub.1为氟原子；当R.sub.2和R.sub.3均为氢原子时，R.sub.1为氟或溴原子。还公开了它们的非毒性酸加盐。这些化合物具有多巴胺能特性，可用于治疗帕金森综合症。公开了用于此类用途的组合物。

  公开号：

  US04003932A1

文献信息

• New prenylamine analogues: synthesis and Ca2+-entry blocking activity
  作者：PM Caldirola、H van der Goot、H Timmerman

  DOI：10.1016/0223-5234(92)90136-o

  日期：1992.9

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.
• Aminoalkylethers
  申请人：Gist-Brocades N.V.

  公开号：US04003932A1

  公开（公告）日：1977-01-18

  Diphenylmethoxyethylamines of the general formula ##STR1## in which R.sub.1 represents a fluorine, bromine or chlorine atom, R.sub.2 represents a hydrogen or fluorine atom and R.sub.3 represents a hydrogen, fluorine or chlorine atom, with the provisos that R.sub.3 is a hydrogen atom when R.sub.2 is a fluorine atom, R.sub.1 is a fluorine atom when R.sub.3 is a chlorine atom and R.sub.1 is a fluorine or bromine atom when R.sub.2 and R.sub.3 both are hydrogen atoms, and their non-toxic acid addition salts are disclosed. The compounds have dopaminergic properties and their use is indicated for treating the Parkinson syndrome. Compositions for such use are disclosed.

  一般式为##STR1##的二苯甲氧基乙胺，其中R.sub.1代表氟、溴或氯原子，R.sub.2代表氢或氟原子，R.sub.3代表氢、氟或氯原子，但有以下限制条件：当R.sub.2为氟原子时，R.sub.3为氢原子；当R.sub.3为氯原子时，R.sub.1为氟原子；当R.sub.2和R.sub.3均为氢原子时，R.sub.1为氟或溴原子。还公开了它们的非毒性酸加盐。这些化合物具有多巴胺能特性，可用于治疗帕金森综合症。公开了用于此类用途的组合物。