2,2'-((3-(diethylamino)propyl)azanediyl)bis(ethan-1-ol) | 58883-81-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2'-((3-(diethylamino)propyl)azanediyl)bis(ethan-1-ol)
• 英文别名: 2,2'-((3-(diethylamino)propyl)azanediyl)bis(ethane-1-ol)；2,2′-((3-(diethylamino)propyl)azanediyl)bis(ethan-1-ol)；N,N-Diaethyl-N',N'-bis-(2-hydroxy-aethyl)-1,3-diamino-propan；2-[3-(Diethylamino)propyl-(2-hydroxyethyl)amino]ethanol
• CAS: 58883-81-1
• 化学式: C₁₁H₂₆N₂O₂
• 分子量: 218.34
• InChiKey: JJTRBLDHULFFNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2'-((3-(diethylamino)propyl)azanediyl)bis(ethan-1-ol) 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 N,N-Diethyl-N',N'-bis-(2-chlor-ethyl)-1,3-diamino-propan
  参考文献：
  名称：

  Aiko,I., Chemical and pharmaceutical bulletin, 1961, vol. 9, p. 343 - 351

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙醇胺 、 3-氯-1-二乙氨基丙烷 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 以2.9 g的产率得到2,2'-((3-(diethylamino)propyl)azanediyl)bis(ethan-1-ol)
  参考文献：
  名称：

  LIPID COMPOSITION

  摘要：

  本发明的目的是提供一种脂质组合物，能够实现对各种核酸的优异递送。根据本发明，提供了一种脂质组合物，其中包含第一脂质，该脂质是由式（1）或其盐所代表的脂质，固醇和核酸，其中第一脂质的摩尔数与固醇的摩尔数之比为0.300或更多，但小于1.299。在公式中，X代表—NR1—或—O—，R1代表氢原子、烃基或类似物，R2和R3各自独立地代表氢原子、烃基或类似物，R4、R5、R6、R7、R8、R9、R10、R11和R12各自独立地代表氢原子或烷基，在R4和R5、R10和R5、R5和R12、R4和R6、R5和R6、R6和R7、R6和R10、R12和R7以及R7和R8中的任意一对中，可以将其相互连接以形成4至7个成员的环，该环中可以含有一个O原子，a、b、c和d各自独立地代表0至3的整数，a+b为1或更多，c+d为1或更多。

  公开号：

  US20220273817A1

文献信息

• Amino alcohol derivatives, process for their production and pharmaceutical preparations and reagents containing these compounds
  申请人：Roche Diagnostics GmbH

  公开号：US20030236266A1

  公开（公告）日：2003-12-25

  The present invention concerns new amino alcohol derivatives, a process for their production as well as pharmaceutical preparations and reagents which contain these substances. The invention concerns pharmaceutical agents of the general formula I 1 in which A denotes hydrogen, a group NR 1 R 2 , a group NR 1 (CH 2 ) p NR 3 R 4 , a group (C═NH)NH 2 or a pyridinyl residue, B and D are the same or different and each denotes a bond, a C 1 to C 6 alkylene residue or a group NR 5 —C 2 to C 6 -alkylene, C denotes piperidinediyl or piperazinediyl, W and X are the same or different and each denotes a bond or a carbonyl group, Y and Z are the same or different and each denotes a saturated or unsaturated hydrocarbon residue with 7 to 24 carbon atoms, R 1 to R 5 are the same or different and each represents hydrogen or a C 1 to C 6 alkyl residue, m is an integer 0, 1 or 2 and if m equals 2 C can also independently of one another be piperidinediyl or piperazinediyl, n and o are the same or different and each denotes the integers 2, 3 or 4 and p denotes an integer from 2 to 6 as well as physiologically tolerated salts thereof, provided that hydrazine derivatives are not included and that m cannot be 0 if A denotes hydrogen or a group (C═NH)NH 2 and B and D being the same or different represent a bond or an alkylene residue.

  本发明涉及新的氨基醇衍生物，其生产方法以及含有这些物质的制药制剂和试剂。该发明涉及通式I1的药用剂，其中A表示氢、基团NR1R2、基团NR1(CH2)pNR3R4、基团(C═NH)NH2或吡啶基,B和D相同或不同，每个表示键、C1到C6烷基残基或基团NR5—C2到C6-烷基,C表示哌啶二基或哌嗪二基,W和X相同或不同，每个表示键或羰基,Y和Z相同或不同，每个表示具有7到24个碳原子的饱和或不饱和碳氢残基，R1到R5相同或不同，每个代表氢或C1到C6烷基残基，m是整数0、1或2，如果m等于2，则C也可以独立地是哌啶二基或哌嗪二基，n和o相同或不同，每个表示整数2、3或4，p表示2到6之间的整数，以及其生理耐受的盐，前提是不包括肼衍生物，并且如果A表示氢或基团(C═NH)NH2，且B和D相同或不同表示键或烷基残基，则m不能为0。
• LIPID COMPOSITION
  申请人：FUJIFILM Corporation

  公开号：US20220096381A1

  公开（公告）日：2022-03-31

  An object of the present invention is to provide a lipid composition making it possible to achieve excellent delivery of nucleic acids. According to the present invention, there is provided a lipid composition containing a lipid represented by Formula (1) or a salt thereof, a nonionic lipid, a lipid having a nonionic hydrophilic polymer structure, and a nucleic acid, in which the lipid composition contains or does not contain a zwitterionic lipid, and in a case where (A) represents a molar ratio in percentage of the lipid represented by Formula (1) or a salt thereof to total lipids constituting the lipid composition and (B) represents a molar ratio in percentage of the zwitterionic lipid to total lipids constituting the lipid composition, (A) and (B) satisfy 40<(A)−(B)≤90. In the formula, X represents —NR 1 — or —O—, R 1 represents a hydrogen atom, a hydrocarbon group, or the like, R 2 and R 3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R 4 and R 5 , R 10 and R 5 , R 5 and R 12 , R 4 and R 6 , R 5 and R 6 , R 6 and R 7 , R 6 and R 10 , R 12 and R 7 , and R 7 and R 8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is 1 or more, and c+d is 1 or more.

  本发明的目的是提供一种脂质组合物，使得核酸的传递能够实现优异。根据本发明，提供一种脂质组合物，其中包含式（1）或其盐所代表的脂质、非离子脂质、具有非离子亲水性聚合物结构的脂质和核酸，所述脂质组合物包含或不包含一个带电离子脂质，且当（A）代表式组成脂质组合物中式（1）或其盐所代表的脂质的摩尔比例百分比，（B）代表式组成脂质组合物中带电离子脂质的摩尔比例百分比时，（A）和（B）满足40 < (A) - (B) ≤ 90。在式中，X代表—NR1—或—O—，R1代表氢原子、烃基或类似物，R2和R3各自独立地代表氢原子、烃基或类似物，R4、R5、R6、R7、R8、R9、R10、R11和R12各自独立地代表氢原子或烷基，R4和R5、R10和R5、R5和R12、R4和R6、R5和R6、R6和R7、R6和R10、R12和R7以及R7和R8中的任意一个或多个成对的基团可以连接在一起形成一个含氧原子的4-7环，a、b、c和d各自独立地代表0到3的整数，a+b≥1，c+d≥1。
• CATALYST COMPOSITION FOR PRODUCTION OF POLYURETHANE RESIN AND METHOD FOR PRODUCING POLYURETHANE RESIN (AS AMENDED)
  申请人：Kometani Hiroyuki

  公开号：US20100130629A1

  公开（公告）日：2010-05-27

  Disclosed is a catalyst composition for polyurethane resin production which contains (A) triethylenediamine, (B) a specific polyisocyanurating catalyst and/or (C) a specific highly temperature-sensitive catalyst. By using this catalyst composition, a polyurethane resin can be molded with good curability, while suppressing initial reactivity. Consequently, a polyurethane resin having excellent moldability and fluidity can be produced with high productivity by using the catalyst composition. The thus-obtained polyurethane resin is suitably applicable to shoe soles. The component (B) is selected from the group consisting of alkali metal salts of carboxylic acids, quaternary ammonium compounds expressed as R 1 R 2 R 3 R 4 N + ,X − , N,N,N′-trimethylaminoethylethanolamine, and 2,4,6-tris(dimethylaminomethyl)phenol, while the component (C) is selected from the group consisting of triazole salts and benzotriazole salts of 1,8-diazabicyclo[5.4.0]undecene-7 or 1,5-diazabicyclo[4.3.0]nonene-5. The mixing ratio of the component (B) and/or the component (C) to the component (A) is from 2% by weight to 60% by weight.

  本发明涉及一种用于聚氨酯树脂生产的催化剂组合物，其包含（A）三乙二胺，（B）特定的聚异氰酸酯催化剂和/或（C）特定的高温敏感催化剂。通过使用这种催化剂组合物，可以制造具有良好可固化性的聚氨酯树脂，同时抑制初始反应性。因此，使用催化剂组合物可以生产具有出色的可塑性和流动性的聚氨酯树脂，并具有高生产率。因此制造的聚氨酯树脂适用于鞋底。组分（B）选自羧酸的碱金属盐、表示为R1R2R3R4N+，X−的季铵化合物、N，N，N′-三甲基氨基乙基乙醇胺和2,4,6-三（二甲胺甲基）苯酚组成的群，而组分（C）选自1,8-二氮杂双环[5.4.0]十一烯-7或1,5-二氮杂双环[4.3.0]壬烯-5的三唑盐和苯并三唑盐组成的群。组分（B）和/或组分（C）与组分（A）的混合比重为2重量％至60重量％。
• 화합물 또는 그 염, 지질 입자 및 의약 조성물
  申请人：후지필름 가부시키가이샤

  公开号：KR20230162043A

  公开（公告）日：2023-11-28

  본 발명은, 높은 핵산 내포율 및 우수한 핵산 송달을 실현할 수 있는 지질 입자를 구성하는 화합물 또는 그 염, 및 이것을 이용한, 높은 핵산 내포율 및 우수한 핵산 송달을 실현할 수 있는 지질 입자 및 의약 조성물을 제공하는 것을 과제로 한다. 본 발명에 의하면, 하기 식 (1)로 나타나는 화합물 또는 그 염이 제공된다. 식 중, 각 기호는, 본 명세서에 정의한 의미를 나타낸다.

  本发明的目的是提供由能够高核酸掺入和优异核酸递送的脂质颗粒组成的化合物或其盐，以及能够高核酸掺入和优异核酸递送的脂质颗粒和使用其的药物组合物。根据本发明，提供了由下式（1）表示的化合物或其盐。式中，各符号具有本文所定义的含义。
• Catalyst composition for the production of a polyurethane resin, and method for producing a polyurethane resin
  申请人：Tosoh Corporation

  公开号：EP1092737A2

  公开（公告）日：2001-04-18

  A catalyst composition for the production of a polyurethane resin, which comprises an amine compound of the following formula (1): wherein each of R1 and R2 which are independent of each other, is a C1-4 alkyl group, such alkyl groups bonded to each other directly or via a nitrogen atom or an oxygen atom to form a ring structure, a dimethylaminopropyl group or a diethylaminopropyl group, and R3 is a C2-16 straight chain or branched chain alkylene group, and an amine compound of the following formula (2): wherein each of R4 and R5 which are independent of each other, is a C1-4 alkyl group, such alkyl groups bonded to each other directly or via a nitrogen atom or an oxygen atom to form a ring structure, a dimethylaminopropyl group or a diethylaminopropyl group, R6 is a C2-16 straight chain or branched chain alkylene group, R7 is a C2-3 straight chain or branched chain alkylene group, and n is an integer of from 0 to 2.

  一种用于生产聚氨酯树脂的催化剂组合物，它包括下式(1)的胺化合物： 其中相互独立的 R1 和 R2 均为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R3 为 C2-16 直链或支链亚烷基，以及下式（2）的胺化合物： R4 和 R5 均为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R3 为 C2-16 直链或支链亚烷基： 其中相互独立的 R4 和 R5 各为 C1-4 烷基，此类烷基直接或通过氮原子或氧原子相互键合以形成环状结构、二甲基氨基丙基或二乙基氨基丙基，R6 为 C2-16 直链或支链亚烷基，R7 为 C2-3 直链或支链亚烷基，n 为 0 至 2 的整数。