[(3Z,5Z,8R,9S,10R,11R,14S,15Z,18R,20R,21Z,24S)-24-[(E,2S,3S,4S,7R,8S,9R,10R)-9-acetyloxy-7-[(2S)-2-(dimethylamino)propanoyl]oxy-12-[formyl(methyl)amino]-3-hydroxy-4,8,10-trimethyldodec-11-en-2-yl]-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxo-1-oxacyclotetracosa-3,5,15,21-tetraen-8-yl] (2S)-2-(dimethylamino)-3-methoxypropanoate | 151923-84-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: [(3Z,5Z,8R,9S,10R,11R,14S,15Z,18R,20R,21Z,24S)-24-[(E,2S,3S,4S,7R,8S,9R,10R)-9-acetyloxy-7-[(2S)-2-(dimethylamino)propanoyl]oxy-12-[formyl(methyl)amino]-3-hydroxy-4,8,10-trimethyldodec-11-en-2-yl]-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxo-1-oxacyclotetracosa-3,5,15,21-tetraen-8-yl] (2S)-2-(dimethylamino)-3-methoxypropanoate
• 英文别名: [(3E,5E,15E,21E)-24-[(E)-9-acetyloxy-7-[2-(dimethylamino)propanoyloxy]-12-[formyl(methyl)amino]-3-hydroxy-4,8,10-trimethyldodec-11-en-2-yl]-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxo-1-oxacyclotetracosa-3,5,15,21-tetraen-8-yl] 2-(dimethylamino)-3-methoxypropanoate
• CAS: 151923-84-1
• 化学式: C₅₉H₁₀₁N₃O₁₄
• 分子量: 1076.4
• InChiKey: JMXMEKJLQWJRHY-PNRJZHGSSA-N

物化性质

• 沸点：
  988.8±65.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)
• 溶解度：
  CHCl3, Methanol

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  76
• 可旋转键数：
  25
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  200
• 氢给体数：
  2
• 氢受体数：
  16

文献信息

• [EN] SCALABLE POLYPROPIONATE LACTONE STEREOTETRADS<br/>[FR] STÉRÉOTETRADES DE LACTONE DE POLYPROPIONATE POUVANT ÊTRE MISES À L'ÉCHELLE
  申请人：AKANOCURE PHARMACEUTICALS INC

  公开号：WO2018107180A1

  公开（公告）日：2018-06-14

  The present technology is directed to polypropionate lactone stereotetrads of Formula (I) (or a pharmaceutically acceptable salt and/or solvate thereof) which are significant intermediates for multiple synthetic applications.

  目前的技术涉及公式(I)的聚丙酸内酯立体四元组（或其药用可接受盐和/或溶剂化物），它们是多种合成应用的重要中间体。
• [EN] STEREOCHEMICALLY DEFINED POLYPROPIONATES AND METHODS FOR MAKING AND USING THE SAME<br/>[FR] POLYPROPIONATES DÉFINIS STÉRÉOCHIMIQUEMENT ET PROCÉDÉS POUR LES PRODUIRE ET LES UTILISER
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2016022519A1

  公开（公告）日：2016-02-11

  The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

  本发明涉及立体化定义的聚丙酸酯及其制备和使用方法。这些立体化定义的聚丙酸酯可能在合成天然产物和/或类似天然产物的库中发挥作用。
• [EN] LARGE-SCALE DIASTEREOSELECTIVE SYNTHESES OF CYCLOHEPTADIENYLSULFONES AND STEREOTETRADS<br/>[FR] SYNTHESES DIASTEREOSELECTIVES A GRANDE ECHELLE DE CYCLOHEPTADIENYLSULFONES ET DE STEREOTETRADES
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2016057606A1

  公开（公告）日：2016-04-14

  The invention relates to processes for large-scale diastereoselective syntheses of cycloheptadienylsulfone and stereo tetrads, key intermediates for the preparation of Aplyronine A.

  这项发明涉及大规模立体选择性合成环庚二烯基砜和立体四聚体的过程，这些是制备阿普利罗宁A的关键中间体。
• Compositions and methods for detecting and treating HIV infection
  申请人：George Mason Intellectual Properties, Inc.

  公开号：EP2236620A2

  公开（公告）日：2010-10-06

  HIV infection can be detected by measuring phosphorylation levels of the actin-depolymerizing factor (AFD)/cofilin family, and infection can be treated and/or prevented by modulating the HIV co-receptor signaling pathway.

  通过测量肌动蛋白解聚因子（AFD）/纤维蛋白家族的磷酸化水平，可以检测到艾滋病毒感染；通过调节艾滋病毒共受体信号通路，可以治疗和/或预防感染。
• Stereochemically defined polypropionates and methods for making and using the same
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US10160768B2

  公开（公告）日：2018-12-25

  The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

  本发明涉及立体化学定义的聚丙酸盐及其制备和使用方法。立体化学定义的聚丙酸酯可用于合成天然产物和/或类天然产物库。