3-propyl-1-tosyl-1H-pyrazole | 1276088-12-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-propyl-1-tosyl-1H-pyrazole
• 英文别名: 1-(4-Methylphenyl)sulfonyl-3-propylpyrazole
• CAS: 1276088-12-0
• 化学式: C₁₃H₁₆N₂O₂S
• 分子量: 264.348
• InChiKey: ZZHZMBLUEKZDSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-ethoxy-2-ethylcyclobutanone 、 对甲苯磺酰肼 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以91%的产率得到3-propyl-1-tosyl-1H-pyrazole
  参考文献：
  名称：

  A New Synthesis of Pyrazoles through a Lewis Acid Catalyzed Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines

  摘要：

  A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.

  DOI：

  10.1021/ol2002682

文献信息

• [EN] AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS AZAINDAZOLE EN TANT QU'ANTAGONISTES DES RÉCEPTEURS CCR1
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010036632A1

  公开（公告）日：2010-04-01

  Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

  公开的是化合物的公式（I），用于治疗通过CCR1活性介导或维持的多种疾病和疾病，包括自身免疫性疾病，如风湿性关节炎和多发性硬化症。还公开了制备方法和使用方法。
• AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：EP2346868A1

  公开（公告）日：2011-07-27
• A New Synthesis of Pyrazoles through a Lewis Acid Catalyzed Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines
  作者：Gang Shan、Pengfei Liu、Yu Rao

  DOI：10.1021/ol2002682

  日期：2011.4.1

  A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.