N-Hydroxy-3a(2)-[(3-methoxyphenyl)methoxy][1,1a(2)-biphenyl]-4-carboxamide | 579511-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Hydroxy-3a(2)-[(3-methoxyphenyl)methoxy][1,1a(2)-biphenyl]-4-carboxamide
• 英文别名: N-hydroxy-4-[3-[(3-methoxyphenyl)methoxy]phenyl]benzamide
• CAS: 579511-02-7
• 化学式: C₂₁H₁₉NO₄
• 分子量: 349.4
• InChiKey: MKHHFHWPMZXVND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel bicyclic hydroxamates as inhibitors of histone deacetylase
  申请人：Leahy M Ellen

  公开号：US20060058553A1

  公开（公告）日：2006-03-16

  The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed

  本发明涉及某些双环羟肟衍生物，它们是组蛋白去乙酰化酶的抑制剂，因此可以用于治疗与组蛋白去乙酰化酶活性相关的疾病。本发明还公开了制备这些化合物的制药组合物和过程。
• NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE
  申请人：Axys Pharmaceuticals

  公开号：EP1472216A2

  公开（公告）日：2004-11-03
• [EN] NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] NOUVEAUX HYDROXAMATES BICYCLIQUES SERVANT D'INHIBITEURS DE HISTONE DESACETYLASE
  申请人：AXYS PHARMACEUTICALS

  公开号：WO2003066579A2

  公开（公告）日：2003-08-14

  The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed