(E)-1,2-bis(4-bromophenyl)-2-hydroxy-5-phenylpent-4-en-1-one | 1112237-23-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1,2-bis(4-bromophenyl)-2-hydroxy-5-phenylpent-4-en-1-one
• CAS: 1112237-23-6
• 化学式: C₂₃H₁₈Br₂O₂
• 分子量: 486.203
• InChiKey: QDNXMPKUSDVFQT-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酸肉桂酯 、 对溴苯甲醛 在 3,4-二甲基-5-(2-羟乙基)碘代噻唑 、 potassium carbonate 、 三苯基膦 、 palladium dichloride 作用下， 以 二甲基亚砜 为溶剂， 反应 48.0h， 以91%的产率得到(E)-1,2-bis(4-bromophenyl)-2-hydroxy-5-phenylpent-4-en-1-one
  参考文献：
  名称：

  Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts

  摘要：

  Functionalized a-hydroxy carbonyl compounds were prepared from various aldehydes and allylic acetates via a multicomponent reaction, which were catalyzed by N-heterocyclic carbene and Pd catalysts in one pot. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.032

文献信息

• Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts
  作者：Jinmei He、Shibing Tang、Shouchu Tang、Jian Liu、Yongquan Sun、Xinfu Pan、Xuegong She

  DOI：10.1016/j.tetlet.2008.11.032

  日期：2009.1

  Functionalized a-hydroxy carbonyl compounds were prepared from various aldehydes and allylic acetates via a multicomponent reaction, which were catalyzed by N-heterocyclic carbene and Pd catalysts in one pot. (c) 2008 Elsevier Ltd. All rights reserved.