申请人:Takeda Chemical Industries, Ltd.
公开号:US04150139A1
公开(公告)日:1979-04-17
Novel triazolobenzazepine derivatives of the formula ##STR1## (wherein R.sup.1 and R.sup.2 are hydrogen or alkyl, X is ##STR2## wherein R.sup.3 and R.sup.4 are hydrogen, alkyl, aryl or aralkyl, and R.sup.5 is hydrogen or alkyl), Z is --SR.sup.6, --S(O).sub.n R.sup.6 or --OR.sup.7 (wherein R.sup.6 and R.sup.7 are alkyl or aralkyl, and n is 1 or 2), and Ring A is unsubstituted or substituted with at least one of halogen, lower alkyl, lower alkoxy and trifluoromethyl, and their physiologically acceptable salts have excellent pharmacological activities and are useful as medicines such as muscle-relaxants, analgesics and antiinflammatory drugs.
式 ##STR1## 的新型三唑并苯并氮杂环衍生物(其中 R1 和 R2 为氢或烷基,X 为 ##STR2## 其中 R3 和 R4 为氢、烷基、芳基或芳烷基,R5 为氢或烷基),Z 为 --SR6、--S(O)nR6 或 --OR7(其中 R6 和 R7 为烷基或芳烷基,n 为 1 或 2),且环 A 未被取代或被至少一种卤素、低级烷基、低级烷氧基和三氟甲基取代,及其生理上可接受的盐具有优异的药理活性,并可作为药物如肌肉松弛剂、镇痛剂和抗炎药物使用。