2-羟基-4-(4-甲氧基苯基)苯甲酸 | 221021-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-4-(4-甲氧基苯基)苯甲酸
• 英文名称: 3-Hydroxy-4'-methoxy-biphenyl-4-carboxylic acid
• 英文别名: 2-Hydroxy-4-(4-methoxyphenyl)benzoic acid
• CAS: 221021-30-3
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: CXCJVMMWJCAGIU-UHFFFAOYSA-N

物化性质

• 沸点：
  445.2±45.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-羟基-4-碘苯甲酸 、 三丁基(4-甲氧基苯基)锡 在 Palladacycle lithium chloride 作用下， 以 various solvent(s) 为溶剂， 反应 5.0h， 以55%的产率得到2-羟基-4-(4-甲氧基苯基)苯甲酸
  参考文献：
  名称：

  Palladium-catalyzed coupling of functionalized bromoarenes to a polystyrene-bound aryl tributylstannane

  摘要：

  The Stille reaction with a polystyrene-bound stannyl component, catalyzed by a palladacycle complex, provides a convenient and clean method for the synthesis of substituted biaryls on the resin. Several functional groups useful for the construction of supported polydentate amino alcohols were successfully introduced. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02384-3

文献信息

• Palladium-catalyzed coupling of functionalized bromoarenes to a polystyrene-bound aryl tributylstannane
  作者：Marcus S. Brody、M.G. Finn

  DOI：10.1016/s0040-4039(98)02384-3

  日期：1999.1

  The Stille reaction with a polystyrene-bound stannyl component, catalyzed by a palladacycle complex, provides a convenient and clean method for the synthesis of substituted biaryls on the resin. Several functional groups useful for the construction of supported polydentate amino alcohols were successfully introduced. (C) 1998 Elsevier Science Ltd. All rights reserved.