TAK-070 free base | 212571-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: TAK-070 free base
• 英文别名: N,N-dimethyl-2-[(2R)-6-[(4-phenylphenyl)methoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]ethanamine
• CAS: 212571-56-7
• 化学式: C₂₇H₃₁NO
• 分子量: 385.5
• InChiKey: SETMAZMOXYOEJA-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pharmaceutical preparation containing copolyvidone
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US10098866B2

  公开（公告）日：2018-10-16

  A stabilized preparation which comprises: a unstable drug in a polyethylene glycol-containing preparation; and a coating agent comprising a copolyvidone instead of polyethylene glycol with which the drug is coated.

  一种稳定的制剂，包括：在聚乙二醇含制剂中的不稳定药物；以及一种包衣剂，其包衣剂包括一种共聚维酮，而不是用聚乙二醇包衣药物。
• Beta secretase inhibitors
  申请人：Miyamoto Masaomi

  公开号：US20050228020A1

  公开（公告）日：2005-10-13

  An excellent β secretase inhibitor is provided, which comprises a compound of the general formula: wherein Ar is an aromatic group; X is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO 2 —, —NR 8 —, CONR 8 —, —SO 2 NR 8 —, and —COO— (wherein R 8 is hydrogen, etc.), a divalent C 1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups, or a bond; Y is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO 2 —, —NR 8 —, —CONR 8 —, —SO 2 NR 8 —, and —COO—, or a divalent C 1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups; R 1 and R 2 are hydrogen, a hydrocarbon group, etc., respectively; and A is a ring which may be further substituted, or a salt thereof.

  提供了一种优秀的β-分泌酶抑制剂，其包括一种具有以下通式的化合物：其中Ar为芳香基团；X为二价基团，选自—O—、—S—、—CO—、—SO—、—SO2—、—NR8—、CONR8—、—SO2NR8—和—COO—（其中R8为氢等），一种C1-6链状脂肪基碳氢基团，可以包含其中一种或两种这些二价基团，或一个键；Y为二价基团，选自—O—、—S—、—CO—、—SO—、—SO2—、—NR8—、—CONR8—、—SO2NR8—和—COO—，或一种C1-6链状脂肪基碳氢基团，可以包含其中一种或两种这些二价基团；R1和R2分别为氢、碳氢基团等；A为环，可以进一步取代，或其盐。
• PHARMACEUTICAL PREPARATION CONTAINING COPOLYVIDONE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1334732A1

  公开（公告）日：2003-08-13

  A stabilized preparation which comprises: a unstable drug in a polyethylene glycol-containing preparation; and a coating agent comprising a copolyvidone instead of polyethylene glycol with which the drug is coated.

  一种稳定制剂，包括：含聚乙二醇制剂中的不稳定药物；以及由共聚维酮代替聚乙二醇组成的包衣剂，药物用其包衣。
• REMEDIES FOR MILD RECOGNITION DEFLICT
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1459764A1

  公开（公告）日：2004-09-22

  It is intended to provide agents for treating mild cognitive impairment which comprise compounds having an effect of inhibiting the production, secretion, aggregation, and/or accumulation of β-amyloid proteins, prodrugs thereof or salts of the same and inhibit the progress of mild cognitive impairment to Alzheimer's disease using the same.

  本发明旨在提供用于治疗轻度认知障碍的制剂，这些制剂包括具有抑制β-淀粉样蛋白的产生、分泌、聚集和/或积聚作用的化合物、其原药或盐，并利用这些制剂抑制轻度认知障碍向阿尔茨海默病的发展。
• METHOD OF SCREENING TRANSMEMBRANE ENZYME INHIBITORY SUBSTANCE
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1801232A1

  公开（公告）日：2007-06-27

  The present invention provides a screening method for a compound inhibiting a transmembrane enzyme activity by binding to a transmembrane region of the enzyme, characterized by using (a) a protein having a part or all of an amino acid sequence of the enzyme, comprising a region comprising an active center and a part or all of a transmembrane region of the transmembrane enzyme, and optionally (b) a protein having a part of an amino acid sequence of the transmembrane enzyme, comprising the region comprising the active center and lacking the above-mentioned part or all of the transmembrane region, and measuring the binding of a test substance to each protein and the enzyme activity of each protein, as well as a kit for screening comprising the above-mentioned protein of (a) and (b). Also, the present invention provides a β-secretase selective inhibitor comprising a β-secretase inhibiting substance binding to a transmembrane region of the enzyme, and particularly an inhibitor for prophylaxis and/or treatment of Alzheimer's disease, Down syndrome or Age-Associated Memory Impairment.

  本发明提供了一种通过与跨膜酶的跨膜区结合来抑制该酶活性的化合物的筛选方法，其特征在于使用(a)具有该酶的部分或全部氨基酸序列的蛋白质，该蛋白质包括由活性中心和跨膜酶的部分或全部跨膜区组成的区域、和可选的(b)具有跨膜酶的部分氨基酸序列的蛋白质，包括由活性中心组成的区域和缺少上述部分或全部跨膜区域，测量测试物质与每种蛋白质的结合和每种蛋白质的酶活性，以及包括上述(a)和(b)的蛋白质的筛选试剂盒。另外，本发明还提供了一种β-分泌酶选择性抑制剂，该抑制剂包括与酶的跨膜区结合的β-分泌酶抑制物质，特别是一种用于预防和/或治疗阿尔茨海默病、唐氏综合征或年龄相关记忆损伤的抑制剂。