Benzoylchelidonine, (+)- | 436812-20-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 苯并菲啶生物碱
• 英文名称: Benzoylchelidonine, (+)-
• 英文别名: [(1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-yl] benzoate
• CAS: 436812-20-3
• 化学式: C₂₇H₂₃NO₆
• 分子量: 457.483
• InChiKey: OJUONBUZEDFJPA-CCDWMCETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯甲酰氯 、 白屈菜碱 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以71.1%的产率得到Benzoylchelidonine, (+)-
  参考文献：
  名称：

  Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives

  摘要：

  A group of 11 derivatives of chelidonine was obtained by acylations and/or alkylations of the secondary hydroxyl group with the aim of testing their biological activity. This paper focuses on the new derivatives influence on CNS in mice. The highest activity was observed for compounds 2c, 3c and 4, which produced antinociceptive and antiserotoninergic effects, not recorded for the parent alkaloid 1. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01288-0

文献信息

• Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives
  作者：G Grynkiewicz

  DOI：10.1016/s0223-5234(01)01288-0

  日期：2001.12.1

  A group of 11 derivatives of chelidonine was obtained by acylations and/or alkylations of the secondary hydroxyl group with the aim of testing their biological activity. This paper focuses on the new derivatives influence on CNS in mice. The highest activity was observed for compounds 2c, 3c and 4, which produced antinociceptive and antiserotoninergic effects, not recorded for the parent alkaloid 1. (C) 2001 Editions scientifiques et medicales Elsevier SAS.