threo-1-amino-1,2-diphenylpropane

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: threo-1-amino-1,2-diphenylpropane
• 英文别名: 1,2-diphenylpropan-1-amine；1,2-diphenylpropan-1-amine(anti-3ak)and；(+/-)-threo-1,2-Diphenyl-propylamin；(1S,2R)-1,2-diphenylpropan-1-amine
• 化学式: C₁₅H₁₇N
• 分子量: 211.307
• InChiKey: ONMSXYYIRIBHOQ-DOMZBBRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 threo-1-amino-1,2-diphenylpropane 在 甲酸 作用下， 生成 ((1RS,2SR)-1,2-diphenyl-propyl)-dimethyl-amine
  参考文献：
  名称：

  Christol,H. et al., Bulletin de la Societe Chimique de France, 1963, p. 877 - 881

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二苯基丙酮 在 potassium cyanide 、 lithium aluminium tetrahydride 、 硫酸 作用下， 以 二丁醚 为溶剂， 生成 threo-1-amino-1,2-diphenylpropane
  参考文献：
  名称：

  Christol,H. et al., Bulletin de la Societe Chimique de France, 1963, p. 877 - 881

  摘要：

  DOI：

文献信息

• Alkaline-Metal-Catalyzed One-Pot Aminobenzylation of Aldehydes with Toluenes
  作者：Guoqing Liu、Patrick J. Walsh、Jianyou Mao

  DOI：10.1021/acs.orglett.9b02737

  日期：2019.11.1

  A novel and easily accessible MN(SiMe3)2 (M = Li or Na)/Cs2CO3 co-catalyzed benzylation of in situ generated N-(trimethylsilyl) aldimines with toluene derivatives has been successfully developed. The catalyst exhibits high chemoselectivity for deprotonation of toluenes at the benzylic position. The utility of this system is exemplified by the one-pot synthesis of a diverse array of bioactive 1,2-diarylethylamines

  已成功开发了一种新颖且易于使用的MN（SiMe 3）2（M = Li或Na）/ Cs 2 CO 3催化原位生成的N-（三甲基甲硅烷基）亚胺与甲苯衍生物的苄基化反应。该催化剂对苄基位置的甲苯去质子表现出高化学选择性。一锅合成具有优异效率和宽泛的官能团耐受性的各种生物活性1,2-二芳基乙胺的例子说明了该系统的实用性。
• Catalytic Direct-Type Addition Reactions of Alkylarenes with Imines and Alkenes
  作者：Yasuhiro Yamashita、Hirotsugu Suzuki、Io Sato、Tsubasa Hirata、Shū Kobayashi

  DOI：10.1002/anie.201711291

  日期：2018.6.4

  addition reactions of very weakly acidic nonactivated alkylarenes such as toluene and its derivatives were developed by using a strongly basic mixed catalyst system under mild reaction conditions. The addition reactions with imines and alkenes proceeded smoothly under proton‐transfer conditions to afford the desired products in good to high yields, and high levels of regio‐ and stereoselectivity were achieved

  通过使用强碱性的混合催化剂体系，在温和的反应条件下，开发了弱酸性非活化烷基芳烃（如甲苯）及其衍生物的催化加成反应。在质子转移条件下，与亚胺和烯烃的加成反应可顺利进行，以高到高收率提供所需的产物，并实现了高水平的区域和立体选择性。还显示出烷基亚芳基的不对称加成反应是可能的。
• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND, AND NOVEL METAL-DIAMINE COMPLEX
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20160347678A1

  公开（公告）日：2016-12-01

  The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim 1 ).

  本发明涉及一种制备光学活性化合物的方法，其中包括在氢气作为氢供体和从一组中选择的一种或多种类型的配合物的存在下，对亚胺化合物的亚胺基进行还原或对杂环化合物的不饱和键进行还原的步骤，所述配合物的选择自一组由一般式（1）表示的配合物、一般式（2）表示的配合物、一般式（3）表示的配合物和一般式（4）表示的配合物（一般式（1）-（4）如权利要求1所规定）。
• NOVEL DIAMINE COMPOUND AND METAL COMPLEXES, AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150094468A1

  公开（公告）日：2015-04-02

  The present invention relates to a novel diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand. Furthermore, the present invention relates to methods for selectively producing optically active compounds by using any of these complexes as a catalyst. wherein R 1 , R 2 , R 3 , X, Y, and Z are as defined in claim 1.

  本发明涉及一种由通式（1）表示的新型二胺化合物，一种以该二胺化合物为配体的钌-二胺络合物、铱-二胺络合物和铑-二胺络合物。此外，本发明涉及利用这些络合物中的任何一种作为催化剂选择性生产光学活性化合物的方法。其中，R1、R2、R3、X、Y和Z的定义如权利要求1所述。
• METHOD FOR PRODUCING DIAMINE COMPOUND
  申请人：Touge Taichiro

  公开号：US20140039220A1

  公开（公告）日：2014-02-06

  The present invention provides a method for producing a compound represented by general formula (1) (wherein R 1 , R 2 , R 3 , R 10 -R 14 , A 1 -A 3 , n 1 and n 2 are as defined in the description), which is characterized by reacting a compound represented by general formula (2) (wherein R 10 -R 14 , A 1 -A 3 , n 1 , n 2 and B are as defined in the description) with a diamine compound represented by general formula (3) (wherein R 1 -R 3 are as defined in the description). The present invention is a method for producing a diamine compound, which is useful for the formation of a ruthenium-diamine complex, under mild conditions, said method being able to be put in industrial practice.

  本发明提供了一种生产通式（1）所代表的化合物的方法（其中R1、R2、R3、R10-R14、A1-A3、n1和n2如说明书所定义），其特征在于将通式（2）所代表的化合物（其中R10-R14、A1-A3、n1、n2和B如说明书所定义）与通式（3）所代表的二胺化合物（其中R1-R3如说明书所定义）反应。本发明是一种生产二胺化合物的方法，该方法适用于在温和条件下形成钌-二胺配合物，且能够在工业实践中应用。