2.3.5-Tri-O-benzoyl-2-C-methyl-α-D-ribofuranose | 30361-17-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2.3.5-Tri-O-benzoyl-2-C-methyl-α-D-ribofuranose
• 英文别名: [(2R,3R,4R,5S)-3,4-dibenzoyloxy-5-hydroxy-4-methyloxolan-2-yl]methyl benzoate
• CAS: 30361-17-2
• 化学式: C₂₇H₂₄O₈
• 分子量: 476.483
• InChiKey: NGOREDWQTFTUTC-PDMAMLTQSA-N

物化性质

• 沸点：
  617.7±55.0 °C(Predicted)
• 密度：
  1.35

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Process for the preparation of ribofuranose derivatives
  申请人：——

  公开号：US20040158059A1

  公开（公告）日：2004-08-12

  The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): 1 useful in the synthesis of nucleotides.

  本发明涉及一种从2-C-甲基-D-核糖-1,4-内酯开始的新的三步过程，用于制备式（I）的四酰基核黄酮糖衍生物，其在核苷酸的合成中有用。
• [EN] PROCESS FOR THE PREPARATION OF RIBOFURANOSE DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DU RIBOFURANOSE
  申请人：INALCO SPA

  公开号：WO2004069851A1

  公开（公告）日：2004-08-19

  The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of Formula (I) useful in the synthesis of nucleotides.

  本发明涉及一种从2-C-甲基-D-核糖戊糖内酯出发的3步新工艺，用于制备式(I)的四酰基核黄酮糖衍生物，该衍生物在核苷酸合成中有用。
• [EN] METHODS OF INHIBITING ORTHOPOXVIRUS REPLICATION WITH NUCLEOSIDE COMPOUNDS<br/>[FR] PROCEDE D'INHIBITION DE LA REPLICATION D'ORTHOPOXVIRUS AVEC DES COMPOSES DE NUCLEOSIDE
  申请人：MERCK & CO INC

  公开号：WO2003068244A1

  公开（公告）日：2003-08-21

  The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.

  本发明提供了使用某些核苷类化合物及其衍生物抑制正痘病毒复制和/或治疗正痘病毒感染的方法。这些化合物特别适用于抑制天花病毒和痘病毒的复制和/或治疗天花病毒和痘病毒感染。这些核苷类化合物可以单独或与其他对抗正痘病毒感染的药物联合使用，特别是对抗天花病毒或痘病毒感染的药物。本发明的另一个方面提供了将这些核苷类化合物用于制造药物，以抑制正痘病毒复制和/或治疗正痘病毒感染。本发明的另一个方面提供了这些核苷类化合物作为药物，以抑制正痘病毒复制和/或治疗正痘病毒感染。
• 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
  申请人：——

  公开号：US20040077587A1

  公开（公告）日：2004-04-22

  The 3′-L-valine ester of &bgr;-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery, compounds, compositions, methods and uses are provided for the treatment of flaviviridae, including HCV, that include the administration of an effective amount of val-mCyd or its salt, ester, prodrug or derivative, optionally in a pharmaceutically acceptable carrier. In an alternative embodiment, val-mCyd is used to treat any virus that replicates through an RNA-dependent RNA polymerase.

  &bgr;-D-2′-C-甲基核糖苷鸟苷的3'-L-缬氨酸酯提供了对黄病毒和猪瘟病毒（包括丙型肝炎病毒）更好的结果。基于这一发现，提供了用于治疗黄病毒科（包括HCV）的化合物、组合物、方法和用途，其中包括在药学上可接受的载体中投与有效量的缬氨酸酯-mCyd或其盐、酯、前药或衍生物。在另一种实施方式中，缬氨酸酯-mCyd被用于治疗任何通过RNA依赖性RNA聚合酶复制的病毒。
• Methods of inhibiting orthopoxvirus replication with nucleoside compounds
  申请人：Olsen B. David

  公开号：US20050164960A1

  公开（公告）日：2005-07-28

  The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.

  本发明提供了使用某些核苷类化合物及其衍生物来抑制正痘病毒复制和/或治疗正痘病毒感染的方法。这些化合物特别适用于抑制天花病毒和痘病毒的复制和/或治疗天花病毒和痘病毒感染。这些核苷类化合物可以单独或与其他对抗正痘病毒感染的药物联合使用，特别是对抗天花病毒或痘病毒感染的药物。本发明的另一方面提供了将这些核苷类化合物用于制造用于抑制正痘病毒复制和/或治疗正痘病毒感染的药物。本发明的另一个方面提供了这些核苷类化合物作为用于抑制正痘病毒复制和/或治疗正痘病毒感染的药物。