1-[4-[(2,4-Dimethylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one | 661453-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-[(2,4-Dimethylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
• CAS: 661453-36-7
• 化学式: C₃₄H₃₆N₂O
• 分子量: 488.673
• InChiKey: PSEHTODILBVIHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-((2,4-dimethylphenyl)(phenyl)methyl)piperazine 、 3,3-二苯基丙酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 生成 1-[4-[(2,4-Dimethylphenyl)-phenylmethyl]piperazin-1-yl]-3,3-diphenylpropan-1-one
  参考文献：
  名称：

  Structure–activity relationships of diphenylpiperazine N-type calcium channel inhibitors

  摘要：

  A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.008

文献信息

• Calcium channel blockers comprising two benzhydril moieties
  申请人：——

  公开号：US20040259866A1

  公开（公告）日：2004-12-23

  Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

  描述了一些对哌嗪取代化合物，这些化合物对改变钙通道活性有用。
• CALCIUM CHANNEL BLOCKERS COMPRISING TWO BENZHYDRIL MOIETIES
  申请人：Neuromed Technologies, Inc.

  公开号：EP1610792B1

  公开（公告）日：2007-10-10
• AUTHENTICATION METHOD AND SYSTEM FOR AUTHENTICATING SECURITY DOCUMENTS, SECURITY DOCUMENT AND SECURITY ELEMENT
  申请人：VHP Veiligheidspapierfabriek Ugchelen B.V.

  公开号：EP1839279A2

  公开（公告）日：2007-10-03
• [EN] AUTHENTICATION METHOD AND SYSTEM FOR AUTHENTICATING SECURITY DOCUMENTS, SECURITY DOCUMENT AND SECURITY ELEMENT<br/>[FR] PROCEDE ET SYSTEME D'AUTHENTIFICATION SERVANT A AUTHENTIFIER DES DOCUMENTS CONFIDENTIELS, DOCUMENT CONFIDENTIEL ET ELEMENT DE SECURITE
  申请人：VHP UGCHELEN BV

  公开号：WO2006078154A2

  公开（公告）日：2006-07-27

  [EN] An authentication system for authenticating security documents contains at least an enzyme and a substrate and any co-enzymes and/or co-factors needed, capable of an enzymatic conversion. This conversion leads to a detectable change. The security- document contains at least one of the enzyme and the substrate. According to the invention the genetic information for the enzyme is derived from an extremophilic micro-organism. A security document for use in the authentication system and method is also described.
  [FR] Système d'authentification servant à authentifier des documents confidentiels et contenant au moins un enzyme, un substrat et les co-enzymes et/ou co-facteurs nécessaires, capables de subir une conversion enzymatique. Cette conversion permet d'obtenir une modification détectable. Le document confidentiel contient au moins soit l'enzyme, soit le substrat. D'après l'invention, l'information génétique concernant l'enzyme provient d'un micro-organisme extrêmophile. L'invention concerne également un document confidentiel conçu pour être utilisé dans ce système et ce procédé d'authentification.