2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid sodium salt | 27296-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid sodium salt
• 英文别名: 2,6-dimethyl-3,5-diethoxycarbonyl-4-(Na-carboxylate)-1,4-dihydropyridine；sodium 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinate；3,5-Diethyl 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-3,4,5-pyridinetricarboxylate monosodium salt；sodium;3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate
• CAS: 27296-05-5
• 化学式: C₁₄H₁₈NO₆*Na
• 分子量: 319.29
• InChiKey: DBROLRZEUAZZAL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.37
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid sodium salt 在 亚硝酸氧盐 、 苯甲酸 作用下， 以 phosphate buffer 为溶剂， 反应 0.08h， 以100%的产率得到2,6-二甲基吡啶-3,5-二甲酸二乙酯
  参考文献：
  名称：

  Reaction of derivatives of 1,4-dihydropyridine with the peroxynitrite anion

  摘要：

  DOI：

  10.1007/bf02290724

文献信息

• Plasma stability and cytotoxicity of lipophilic daunorubicin derivatives incorporated into low density lipoproteins
  作者：M Masquelier

  DOI：10.1016/s0223-5234(00)00139-2

  日期：2000.4

  The selective targeting of antineoplastic drugs to tumours by incorporation in low density lipoproteins (LDL) is an attractive possibility if the drug-LDL complex remains stable in the circulation and is taken up by the tumour. In previous studies we have shown that vincristine- and N-trifluoroacetyladriamycin-14-valerate-LDL complexes were unstable in vivo. We synthesized five N-substituted lipophilic derivatives of daunorubicin and studied their incorporation into LDL. Three out of five daunorubicin derivatives incorporated successfully into LDL. In vitro these complexes were more cytotoxic towards LDL receptor positive Chinese hamster ovary cells than LDL receptor negative cells. Non-specific cytotoxicity was explained by slow dissociation of the drug-LDL complex in plasma. Our results underline the importance of careful studies of plasma stability when investigating lipoproteins and other carriers in drug targeting. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
• Reaction of derivatives of 1,4-dihydropyridine with the peroxynitrite anion
  作者：G. Tirzitis、E. Kazush、G. Duburs

  DOI：10.1007/bf02290724

  日期：1998.3