2,3,5,7-tetramethyl-2,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione | 98953-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2,3,5,7-tetramethyl-2,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione
• 英文别名: 2,3,5,7-Tetramethyl-2,7-dihydro-pyrazolo[3,4-d]pyrimidin-4,6-dion；2,3,5,7-tetramethyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione；2,3,5,7-tetramethylpyrazolo[3,4-d]pyrimidine-4,6-dione
• CAS: 98953-92-5
• 化学式: C₉H₁₂N₄O₂
• 分子量: 208.22
• InChiKey: BDEMHHQEBKKRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3,5,7-tetramethyl-2,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 、 碳酸二甲酯 在 sodium hydride 作用下， 以 mineral oil 为溶剂， 生成 methyl (2,5,7-trimethyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl)acetate
  参考文献：
  名称：

  [EN] FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS
  [FR] DÉRIVÉS DE PYRIMIDINEDIONES FUSIONNÉS UTILISÉS COMME MODULATEURS DES RÉCEPTEURS TRPA1

  摘要：

  本发明描述的是一类新颖的杂合吡啶二酮衍生物，其化学公式为（I），这些衍生物是TRPA（瞬时受体电位亚家族A）的调节剂。特别是，本文所述的化合物对于治疗或预防由TRPA1（瞬时受体电位亚家族A成员1）调控的疾病、状况和/或失调是有用的。本发明还提供了制备所述化合物、它们合成中使用的中间体、药物组合物以及治疗或预防由TRPA1调控的疾病、状况和/或失调的方法。公式（I）

  公开号：

  WO2010109287A1
• 作为产物：
  描述：

  5-acetyl-6-(N,N'-diacetyl-hydrazino)-1,3-dimethyl-1H-pyrimidine-2,4-dione 在 sodium hydroxide 作用下， 生成 2,3,5,7-tetramethyl-2,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione
  参考文献：
  名称：

  Pfleiderer; Schuendehuette, Justus Liebigs Annalen der Chemie, 1958, vol. 615, p. 42,47

  摘要：

  DOI：

文献信息

• 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS
  申请人：Kumar Sukeerthi

  公开号：US20120157411A1

  公开（公告）日：2012-06-21

  The present invention is related to 2-amino-4-arylthiazole derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及2-氨基-4-芳基噻唑衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。具体来说，本文描述的化合物对于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、症状和/或疾病具有用处。本文还提供了制备所述化合物的方法，用于合成它们的中间体，它们的药物组成物，以及治疗或预防由TRPA1调节的疾病、症状和/或疾病的方法。
• FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPAI MODULATORS
  申请人：Chaudhari Sachin Sundarlal

  公开号：US20120041004A1

  公开（公告）日：2012-02-16

  The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及化合物公式(I)的新型融合嘧啶二酮衍生物，其为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本发明所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、状况和/或障碍。本发明还提供了制备所述化合物的方法、用于其合成的中间体、其制药组合物以及用于治疗或预防由TRPA1调节的疾病、状况和/或障碍的方法。
• 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS
  申请人：Glenmark Pharmaceuticals, S.A.

  公开号：US20140051667A1

  公开（公告）日：2014-02-20

  The present invention is related to 2-amino-4-arylthiazole derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及2-氨基-4-芳基噻唑衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本文所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、病况和/或疾患。本文还提供了制备所述化合物的过程、用于其合成的中间体、其制药组合物以及治疗或预防由TRPA1调节的疾病、病况和/或疾患的方法。
• Fused pyrimidine-dione derivatives as TRPA1 modulators
  申请人：Chaudhari Sachin Sundarlal

  公开号：US08623880B2

  公开（公告）日：2014-01-07

  The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及公式（I）的新型融合嘧啶二酮衍生物，其为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本文所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、病症和/或障碍。本发明还提供了制备所述化合物的工艺、用于其合成的中间体、其药物组成物以及治疗或预防由TRPA1调节的疾病、病症和/或障碍的方法。
• FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS
  申请人：Glenmark Pharmaceuticals, S.A.

  公开号：US20140128603A1

  公开（公告）日：2014-05-08

  The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及式（I）的新型融合嘧啶二酮衍生物，其为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本发明所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、状况和/或紊乱。本发明还提供了制备所述化合物的方法、用于其合成的中间体、其药物组成物以及用于治疗或预防由TRPA1调节的疾病、状况和/或紊乱的方法。