N⁴-isopropyl-1-methyl-butanediyldiamine | 860544-42-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N⁴-isopropyl-1-methyl-butanediyldiamine
• 英文别名: N⁴-Isopropyl-1-methyl-butandiyldiamin；1-N-propan-2-ylpentane-1,4-diamine
• CAS: 860544-42-9
• 化学式: C₈H₂₀N₂
• 分子量: 144.26
• InChiKey: GXDXQBODUHJQFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-氯吖啶 、 N⁴-isopropyl-1-methyl-butanediyldiamine 在 TEA 、 苯酚 作用下， 生成 N*4*-Acridin-9-yl-N*1*-isopropyl-pentane-1,4-diamine
  参考文献：
  名称：

  N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the α2δ subunit of voltage gated calcium channels

  摘要：

  A series of N-acridin-9-yl-butane-1,4-diamines were found to be high-affinity ligands of the alpha(2)deltasubunit of voltage gated calcium channels. The SAR studies of butane-1,4-diamine side chain resulted in the identification of compound 10 (IC50=9 nM), which is more potent than gabapentin (IC50=27 nM). Partial saturation of the acridine ring was also pursued and provided a compound with higher binding affinity than 1. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.087
• 作为产物：
  描述：

  N-叔丁氧羰基-4-氨基戊酸 在 N-甲基吗啉 、 盐酸 、 sodium tetrahydroborate 、 TEA 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 乙腈 为溶剂， 生成 N⁴-isopropyl-1-methyl-butanediyldiamine
  参考文献：
  名称：

  N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the α2δ subunit of voltage gated calcium channels

  摘要：

  A series of N-acridin-9-yl-butane-1,4-diamines were found to be high-affinity ligands of the alpha(2)deltasubunit of voltage gated calcium channels. The SAR studies of butane-1,4-diamine side chain resulted in the identification of compound 10 (IC50=9 nM), which is more potent than gabapentin (IC50=27 nM). Partial saturation of the acridine ring was also pursued and provided a compound with higher binding affinity than 1. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.087

文献信息

• Quinazoline derivatives useful in cancer treatment
  申请人：Mallams K. Alan

  公开号：US20070032502A1

  公开（公告）日：2007-02-08

  The present invention provides compounds of Formula I (wherein X, m, R 1 , R 2 , R 3 , and R 4 are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.

  本发明提供了公式I的化合物（其中X、m、R1、R2、R3和R4如本文所定义）或其药学上可接受的盐、溶剂或酯。本发明还提供了包含这些化合物的组合物，这些组合物对于治疗细胞增殖性疾病、与p53突变体活性有关的疾病或导致癌细胞凋亡具有用处。
• Sanna; Sequi; Pagletti, Il Farmaco, 1995, vol. 50, # 1, p. 47 - 54
  作者：Sanna、Sequi、Pagletti

  DOI：——

  日期：——
• Pearson; Jones; Cope, Journal of the American Chemical Society, 1946, vol. 68, p. 1227
  作者：Pearson、Jones、Cope

  DOI：——

  日期：——
• Sanna Paolo, Sequi Piera Attilia, Paglietti Giuseppe, Farmaco, 50 (1995) N 1, S 47-54
  作者：Sanna Paolo, Sequi Piera Attilia, Paglietti Giuseppe

  DOI：——

  日期：——
• Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
  申请人：Min Jaeki

  公开号：US20120022070A1

  公开（公告）日：2012-01-26

  Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of treating and preventing cancer and other Hsp90 related diseases and conditions are disclosed that include administering to the subject a therapeutically effective amount of an Hsp90 inhibitor. Methods of preparing the novel Hsp90 inhibitors are also provided.