1-(3-amino-4-methylphenyl)pyrrolidin-2-one | 69132-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-amino-4-methylphenyl)pyrrolidin-2-one
• 英文别名: 1-(3'-Amino-4'-methylphenyl)-pyrrolidin-2-on
• CAS: 69132-82-7
• 化学式: C₁₁H₁₄N₂O
• mdl: MFCD09064650
• 分子量: 190.245
• InChiKey: JPWYHWFXQQVCID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

反应信息

• 作为反应物：
  描述：

  1-(3-amino-4-methylphenyl)pyrrolidin-2-one 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成 1-(3'-Trifluoromethanesulphonamido-4'-methyl-phenyl)-pyrrolidin-2-one
  参考文献：
  名称：

  Novel N-phenyl-substituted N-heterocyclic compounds, their preparation

  摘要：

  本发明涉及具有植物生长抑制和除草作用的新型活性化合物及其制备方法，以及含有这些活性成分的制剂及其用途。这些新型活性化合物是饱和和不饱和的4-7元环氮杂环化合物，氮原子上取代有一个苯基基团，该苯基基团本身携带三氟甲磺酰胺基-NH-SO.sub.2-CF.sub.3作为取代基。苯基基团也可以携带其他取代基，杂环结构也可以被取代。在这些杂环化合物的氧代衍生物中，氧代基最好是邻接于氮原子的，形成了化合物的一个优选亚组。

  公开号：

  US04394156A1

文献信息

• [EN] 1-AKAN-2-OL SUBSTITUTED PIPERAZINE AND PIPERIDINE COMPOUNDS<br/>[FR] COMPOSES PIPERAZINE ET PIPERAZINE 1-AKAN-2-OL SUBSTITUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2005061470A1

  公开（公告）日：2005-07-07

  Disclosed are novel substituted heterocyclic derivatives having the structure of Formula (I): The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.

  揭示了具有以下结构的新型取代杂环衍生物（I）的化合物：这些化合物对于治疗各种疾病状态有用，特别是心血管疾病，如心房和心室心律失常，间歇性跛行，普林兹梅塔（变异）心绞痛，稳定和不稳定心绞痛，运动诱发性心绞痛，充血性心脏病，糖尿病和心肌梗死。
• N-Phenyl-substituted N-heterocyclic compounds, their preparation and use
  申请人：Ciba-Geigy Corporation

  公开号：US04208202A1

  公开（公告）日：1980-06-17

  The present invention relates to novel active compounds having a plant growth-inhibiting and herbicidal action and their preparation and to agents containing these active ingredients, and their use. The novel active compounds are saturated and unsaturated 4-membered to 7-membered ring nitrogen heterocyclic compounds which are substituted on the nitrogen atom by a phenyl radical which itself carries a trifluoromethanesulphonamido group --NH--SO.sub.2 --CF.sub.3 as a substituent. The phenyl radical can also carry other substituents and the heterocyclic structure can also be substituted. Oxo derivatives of the heterocyclic compound, in which the oxo group is preferably adjacent to the nitrogen atom, form a preferred sub-group of compounds.

  本发明涉及具有植物生长抑制和除草作用的新型活性化合物及其制备方法，以及含有这些活性成分的制剂及其用途。这些新型活性化合物是饱和和不饱和的4-7元环氮杂环化合物，氮原子上取代有一个苯基基团，该基团本身携带三氟甲磺胺基--NH--SO.sub.2 --CF.sub.3 作为取代基。苯基基团也可以携带其他取代基，杂环结构也可以被取代。在杂环化合物的氧代衍生物中，氧代基偏好邻近氮原子，形成化合物的一个优选亚组。
• [EN] SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5<br/>[FR] INHIBITEURS DE CDK5 DE TYPE 1,6-NAPHTYRIDINE SUBSTITUÉE
  申请人：GOLDFINCH BIO INC

  公开号：WO2022011274A1

  公开（公告）日：2022-01-13

  Disclosed are compounds having structural formula I, and related salts and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases and conditions such as kidney disease, kidney failure, kidney stones, or polycystic kidney disease, using the compounds of formula (I), and related salts and pharmaceutical compositions.

  揭示了具有结构式I的化合物，以及相关的盐和药物组合物。还揭示了治疗方法，例如利用结构式(I)的化合物、相关盐和药物组合物治疗疾病和病况，如肾病、肾衰竭、肾结石或多囊肾病。
• 1-AKAN-2-OL SUBSTITUTED PIPERAZINE AND PIPERIDINE COMPOUNDS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1723129A1

  公开（公告）日：2006-11-22
• SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5
  申请人：Goldfinch Bio, Inc.

  公开号：US20220389009A1

  公开（公告）日：2022-12-08

  Disclosed are compounds having structural formula I, and related salts and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases and conditions such as kidney disease, kidney failure, kidney stones, or polycystic kidney disease, using the compounds of formula (I), and related salts and pharmaceutical compositions.