N-(3-chloro-4-methoxyphenyl)-6-nitroquinazolin-4-amine | 1290545-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(3-chloro-4-methoxyphenyl)-6-nitroquinazolin-4-amine
• 英文别名: N-(3-Chloro-4-methoxyphenyl)-6-nitroquinazolin-4-amine
• CAS: 1290545-24-2
• 化学式: C₁₅H₁₁ClN₄O₃
• 分子量: 330.73
• InChiKey: GCNHSTAALCLBIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(3-chloro-4-methoxyphenyl)-6-nitroquinazolin-4-amine 在 铁粉 、 溶剂黄146 、 氨 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以69%的产率得到N4-(3-chloro-4-methoxyphenyl)quinazoline-4,6-diamine
  参考文献：
  名称：

  Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates

  摘要：

  A series of N-mustard-quinazoline conjugates was synthesized and subjected to antitumor studies. The N-mustard pharmacophore was attached at the C-6 of the 4-anilinoquinazolines via a urea linker. To study the structure-activity relationships of these conjugates, various substituents were introduced to the C-4 anilino moiety. The preliminary antitumor studies revealed that these agents exhibited significant antitumor activity in inhibiting various human tumor cell growths in vitro. Compounds 21b, 21g, and 21h were selected for further antitumor activity evaluation against human breast carcinoma MX-1 and prostate PC-3 xenograft in animal model. These agents showed 54-75% tumor suppression with low toxicity (5-7% body-weight changes). We also demonstrate that the newly synthesized compounds are able to induce DNA cross-linking through alkaline agarose gel shift assay and inhibited cell cycle arrest at G2/M phase. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.01.055
• 作为产物：
  描述：

  2-氰基-4-硝基苯胺 在 溶剂黄146 作用下， 反应 2.5h， 生成 N-(3-chloro-4-methoxyphenyl)-6-nitroquinazolin-4-amine
  参考文献：
  名称：

  Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates

  摘要：

  A series of N-mustard-quinazoline conjugates was synthesized and subjected to antitumor studies. The N-mustard pharmacophore was attached at the C-6 of the 4-anilinoquinazolines via a urea linker. To study the structure-activity relationships of these conjugates, various substituents were introduced to the C-4 anilino moiety. The preliminary antitumor studies revealed that these agents exhibited significant antitumor activity in inhibiting various human tumor cell growths in vitro. Compounds 21b, 21g, and 21h were selected for further antitumor activity evaluation against human breast carcinoma MX-1 and prostate PC-3 xenograft in animal model. These agents showed 54-75% tumor suppression with low toxicity (5-7% body-weight changes). We also demonstrate that the newly synthesized compounds are able to induce DNA cross-linking through alkaline agarose gel shift assay and inhibited cell cycle arrest at G2/M phase. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.01.055

文献信息

• Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates
  作者：Bhavin Marvania、Pei-Chih Lee、Ravi Chaniyara、Huajin Dong、Sharda Suman、Rajesh Kakadiya、Ting-Chao Chou、Te-Chang Lee、Anamik Shah、Tsann-Long Su

  DOI：10.1016/j.bmc.2011.01.055

  日期：2011.3

  A series of N-mustard-quinazoline conjugates was synthesized and subjected to antitumor studies. The N-mustard pharmacophore was attached at the C-6 of the 4-anilinoquinazolines via a urea linker. To study the structure-activity relationships of these conjugates, various substituents were introduced to the C-4 anilino moiety. The preliminary antitumor studies revealed that these agents exhibited significant antitumor activity in inhibiting various human tumor cell growths in vitro. Compounds 21b, 21g, and 21h were selected for further antitumor activity evaluation against human breast carcinoma MX-1 and prostate PC-3 xenograft in animal model. These agents showed 54-75% tumor suppression with low toxicity (5-7% body-weight changes). We also demonstrate that the newly synthesized compounds are able to induce DNA cross-linking through alkaline agarose gel shift assay and inhibited cell cycle arrest at G2/M phase. (C) 2011 Elsevier Ltd. All rights reserved.