4-amino-2,3-butylene-6-methylthieno[2,3-b]pyridine-5-carboxylic acid | 70291-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 4-amino-2,3-butylene-6-methylthieno[2,3-b]pyridine-5-carboxylic acid
• 英文别名: 4-amino-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-b]pyridine-3-carboxylic acid；4-Amino-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylic acid
• CAS: 70291-60-0
• 化学式: C₁₃H₁₄N₂O₂S
• 分子量: 262.332
• InChiKey: RBIIGTQCVQYCLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 4-amino-5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-b]pyridine-3-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 4-amino-2,3-butylene-6-methylthieno[2,3-b]pyridine-5-carboxylic acid
  参考文献：
  名称：

  Lalezari,I., Journal of Heterocyclic Chemistry, 1979, vol. 16, p. 603 - 604

  摘要：

  DOI：

文献信息

• METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER
  申请人：TACHDJIAN Catherine

  公开号：US20120041078A1

  公开（公告）日：2012-02-16

  The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

  本发明包括在甜味增强剂暴露于光源时稳定一个或多个甜味增强剂的方法，以及包含一个或多个甜味增强剂和一个或多个光稳定剂的液体组合物。
• SWEET FLAVOR MODIFIER
  申请人：TACHDJIAN Catherine

  公开号：US20110245353A1

  公开（公告）日：2011-10-06

  The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

  本发明包括具有结构式(I)的化合物，或其药用可接受的盐、溶剂合物和/或酯。这些化合物可用作甜味调节剂。本发明还包括包含本发明的化合物的组合物以及增强可食用组合物甜味的方法。此外，本发明提供了制备这些化合物的方法。
• Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
  申请人：SENOMYX, INC.

  公开号：US10244779B2

  公开（公告）日：2019-04-02

  The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

  本发明包括当一种或多种增甜剂暴露在光源下时使其稳定的方法，以及含有一种或多种增甜剂和一种或多种光稳定剂的液体组合物。
• SWEETENER COMPOSITION
  申请人：Senomyx, Inc.

  公开号：US20180086751A1

  公开（公告）日：2018-03-29

  Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products. The formulations include combinations of any one or more sweetener in combination with any one or more flavor modifying compound described or referenced herein.
• US8592592B2
  申请人：——

  公开号：US8592592B2

  公开（公告）日：2013-11-26