1,3-dibenzyl-[1,3]diazetidine-2,4-dione | 57198-50-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dibenzyl-[1,3]diazetidine-2,4-dione
• 英文别名: 1,3-Dibenzyl-1,3-diazetidine-2,4-dione
• CAS: 57198-50-2
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: PGIXYPNBNAOYHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异氰酸苄酯 在 1,2-二甲基咪唑 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到1,3-dibenzyl-[1,3]diazetidine-2,4-dione
  参考文献：
  名称：

  Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones

  摘要：

  The present work demonstrates that the 1,3-diazetidifie-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and alpha -chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00264-5

文献信息

• RICHTER R.; ULRICH H., SYNTHESIS <SYNT-BF>, 1975, NO 7, 463-464
  作者：RICHTER R.、 ULRICH H.

  DOI：——

  日期：——
• Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones
  作者：Yasunori Aoyama、Masaaki Uenaka、Toshiro Konoike、Yoko Hayasaki-Kajiwara、Noriyuki Naya、Masatoshi Nakajima

  DOI：10.1016/s0960-894x(01)00264-5

  日期：2001.7

  The present work demonstrates that the 1,3-diazetidifie-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and alpha -chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase. (C) 2001 Elsevier Science Ltd. All rights reserved.