N-(2-nitrophenoxy)piperidine | 78019-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-nitrophenoxy)piperidine
• 英文别名: 1-(2-nitrophenoxy)-piperidine；1-(2-Nitrophenoxy)piperidine
• CAS: 78019-98-4
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.244
• InChiKey: MNWFMLVXRUBWNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-nitrophenoxy)-piperidine 、 N-(2-nitrophenoxy)piperidine 生成 哌啶
  参考文献：
  名称：

  KHUTHIER, A. -H.;AL-KAZZAZ, A. -K. S.;AL-RAWI, J. M. A.;AL-IRAQI, M. A., J. ORG. CHEM., 1981, 46, N 18, 3634-3638

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-nitrophenyl)piperidine N-oxide 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 N-(2-nitrophenoxy)piperidine
  参考文献：
  名称：

  Studies in tertiary amine oxides. Part V—carbon-13 nuclear magnetic resonance spectra of someN-aryl tertiary amines, the correspondingN-oxides and the meisenheimer rearrangement products

  摘要：

  AbstractThe carbon‐13 NMR spectra of some N‐(2‐ or 4‐nitrophenyl) tertiary amines and their corresponding N‐oxides have been analysed. These N‐oxides undergo thermal rearrangement to O‐arylhydroxylamines, for which the 13C NMR spectral assignments were also carried out. The N‐oxidation effect on the aromatic and aliphatic fragments is calculated.

  DOI：

  10.1002/mrc.1270180212

文献信息

• 3-Methylenespiro [benzofuran-piperidines], intermediates and a process for the preparation thereof, and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0275962A2

  公开（公告）日：1988-07-27

  Novel 3-methylenespriro[benzofuran-2(3H),4'-piperidines], intermediates and processes for the preparation thereof are disclosed. The compounds of the invention exhibit blood pressure reducing activity and can therefore be used as medicaments.

  本发明公开了新型 3-亚甲基三[苯并呋喃-2(3H),4'-哌啶]、中间体及其制备工艺。 本发明的化合物具有降血压活性，因此可用作药物。
• Studies of tertiary amine oxides. 4. Thermal rearrangement of N-aryl amine oxides to O-arylhydroxylamines
  作者：Abdul-Hussain Khuthier、Abdul-Khalik S. Al-Kazzaz、Jasim M. A. Al-Rawi、Mohammed A. Al-Iraqi

  DOI：10.1021/jo00331a010

  日期：1981.8
• Studies in tertiary amine oxides. Part V—carbon-13 nuclear magnetic resonance spectra of someN-aryl tertiary amines, the correspondingN-oxides and the meisenheimer rearrangement products
  作者：Abdul-Hussain Khuthier、Jasim M. A. Al-Rawi、Abdul K. Al-Kazzaz、Mohammed A. Al-Iraqi

  DOI：10.1002/mrc.1270180212

  日期：1982.2

  AbstractThe carbon‐13 NMR spectra of some N‐(2‐ or 4‐nitrophenyl) tertiary amines and their corresponding N‐oxides have been analysed. These N‐oxides undergo thermal rearrangement to O‐arylhydroxylamines, for which the 13C NMR spectral assignments were also carried out. The N‐oxidation effect on the aromatic and aliphatic fragments is calculated.
• KHUTHIER, ABDUL-HUSSAIN;AL-MALLAH, KHAWLA Y.;HANNA, SALIM Y., J. CHEM. SOC. PERKIN TRANS.,(1987) N 2, 109-112
  作者：KHUTHIER, ABDUL-HUSSAIN、AL-MALLAH, KHAWLA Y.、HANNA, SALIM Y.

  DOI：——

  日期：——
• US4788201A
  申请人：——

  公开号：US4788201A

  公开（公告）日：1988-11-29

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