N-methyl-N-(4-hydroxyphenethyl)acetamide | 857945-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-methyl-N-(4-hydroxyphenethyl)acetamide
• 英文别名: N-(4-hydroxyphenethyl)-N-methylacetamide；N-(4-Hydroxy-phenaethyl)-N-methyl-acetamid；N-Methyl-N-acetyl-4-oxy-β-phenaethylamin；N-[2-(4-hydroxyphenyl)ethyl]-N-methylacetamide
• CAS: 857945-29-0
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: QIGMGIJAQRCUGN-UHFFFAOYSA-N

物化性质

• 熔点：
  143 °C
• 沸点：
  363.3±25.0 °C(Predicted)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-N-(4-hydroxyphenethyl)acetamide 在 盐酸 作用下， 生成 N-甲基酪胺
  参考文献：
  名称：

  Interactive Effect of Support From Family and Friends in Visually Impaired Elders

  摘要：

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.

  DOI：

  10.1093/geronb/56.6.p374
• 作为产物：
  描述：

  N-甲基-L-酪氨酸 在 芴 作用下， 生成 N-methyl-N-(4-hydroxyphenethyl)acetamide
  参考文献：
  名称：

  甲基酪氨酸二甲基硫酸盐及其衍生物

  摘要：

  酪氨酸二酪胺在酪氨酸-酪氨酸-丁二酮-对甲氧基苯甲酸酯中的应用。Tyrosinbetainbzw。乐观主义者Ratanhin。N-甲基酪氨酸，3-硝基-N-甲基酪氨酸，3-硝基-N-甲基酪氨酸，3-硝基-N-甲基-N-甲基-N-乙酰基酪氨酸，3-氨基-N-甲基-N-乙酰酪氨酸和3-氨基-N-甲基酪氨酸酯。

  DOI：

  10.1002/hlca.19490320309

文献信息

• Catalytic S _N Ar Hydroxylation and Alkoxylation of Aryl Fluorides
  作者：Qi‐Kai Kang、Yunzhi Lin、Yuntong Li、Lun Xu、Ke Li、Hang Shi

  DOI：10.1002/anie.202106440

  日期：2021.9.6

  mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), experimental data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, we isolated a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized

  亲核芳香取代 (S N Ar) 是一种通过用亲核试剂取代离去基团将杂原子结合到芳香环中的强大策略，但这种方法仅限于缺电子芳烃。我们现在已经建立了一种通过催化 S N Ar 反应获取苯酚和苯基烷基醚的可靠方法。该方法适用于广泛的富电子和中性芳基氟化物，它们在经典的 S N Ar 条件下呈惰性。虽然 S N的机制假设涉及金属芳烃配合物的 Ar 反应涉及逐步途径（添加后消除），支持该假设的实验数据仍在探索中。机械研究和 DFT 计算表明了一个逐步或逐步的能量分布。值得注意的是，我们分离了铑 η 5 -环己二烯基复合中间体，其具有带有亲核试剂和离去基团的 sp 3 -杂化碳。
• Isolation, Synthesis, and Biological Activity of Aphrocallistin, an Adenine-Substituted Bromotyramine Metabolite from the Hexactinellida Sponge <i>Aphrocallistes beatrix</i>
  作者：Amy E. Wright、Gregory P. Roth、Jennifer K. Hoffman、Daniela B. Divlianska、Diana Pechter、Susan H. Sennett、Esther A. Guzmán、Patricia Linley、Peter J. McCarthy、Tara P. Pitts、Shirley A. Pomponi、John K. Reed

  DOI：10.1021/np900183v

  日期：2009.6.26

  A new adenine-substituted bromotyrosine-derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix. Its structure was elucidated on the basis of spectral data and confirmed through a convergent, modular total synthetic route that is amenable toward future analogue preparation. Aphrocallistin inhibits the growth of a panel of human tumor cell lines with IC50 values ranging from 7.5 to > 100 mu M and has been shown to induce G1 cell cycle arrest in the PANC-1 pancreatic carcinoma cell line. Aphrocallistin has been fully characterized in the NCI cancer cell line panel and has undergone in vitro ADME pharmacological profiling.
• Über Ergebnisse der Methylierung von Tyrosin mit Dimethylsulfat und einige Derivate des N-Methyltyramins
  作者：Ulrich A. Corti

  DOI：10.1002/hlca.19490320309

  日期：——

  Dimethylsulfat liefert bei der Reaktion mit natürlichem Tyrosin–je nach den Versuchsbedingungen–p-Methoxyzimtsäure bzw. Tyrosinbetain bzw. optisch-aktives Ratanhin. Aus dem bei der Decarboxylierung des Ratanhins erhaltenen N-Methyltyramin wurden N-Acetyl-N-Methyltyramin, 3-Nitro-N-Methyltyramin, 3-Nitro-N-methyl-N-methyl-N-acetyltyramin, 3-Amino-N-methyl-N-acetyltyramin und 3-Amino-N-methyltyramin hergestellt

  酪氨酸二酪胺在酪氨酸-酪氨酸-丁二酮-对甲氧基苯甲酸酯中的应用。Tyrosinbetainbzw。乐观主义者Ratanhin。N-甲基酪氨酸，3-硝基-N-甲基酪氨酸，3-硝基-N-甲基酪氨酸，3-硝基-N-甲基-N-甲基-N-乙酰基酪氨酸，3-氨基-N-甲基-N-乙酰酪氨酸和3-氨基-N-甲基酪氨酸酯。
• Interactive Effect of Support From Family and Friends in Visually Impaired Elders
  作者：J. M. McIlvane、J. P. Reinhardt

  DOI：10.1093/geronb/56.6.p374

  日期：2001.11.1

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.