Methyl 2-[(2,4-dichlorobenzoyl)amino]-5-(2-formyl-3-thienyl)benzoate | 485823-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-[(2,4-dichlorobenzoyl)amino]-5-(2-formyl-3-thienyl)benzoate
• 英文别名: methyl 2-[(2,4-dichlorobenzoyl)amino]-5-(2-formyl-thien-3-yl)benzoate；Methyl 2-[(2,4-dichlorobenzoyl)amino]-5-(2-formylthiophen-3-yl)benzoate；methyl 2-[(2,4-dichlorobenzoyl)amino]-5-(2-formylthiophen-3-yl)benzoate
• CAS: 485823-97-0
• 化学式: C₂₀H₁₃Cl₂NO₄S
• 分子量: 434.3
• InChiKey: RIZATKGMHRXSAS-UHFFFAOYSA-N

物化性质

• 沸点：
  543.2±50.0 °C(Predicted)
• 密度：
  1.464±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds
  申请人：——

  公开号：US20030073862A1

  公开（公告）日：2003-04-17

  The present invention relates to 2-(benzoylamino)benzoic acid derivatives of the formula I 1 wherein the variants Ar, X and R are as described in the specification. The said compounds modulate the activity of peroxisome proliferator-activated receptors (PPAR) &agr; and/or &ggr;, and are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes.

  本发明涉及式I1的2-(苯甲酰氨基)苯甲酸衍生物，其中变体Ar、X和R如规范中所述。所述化合物调节过氧化物酶增殖物激活受体(PPAR)α和/或γ的活性，并预计可用于治疗代谢性疾病，例如II型糖尿病。
• [EN] NEW COMPOUNDS<br/>[FR] COMPOSES NOUVEAUX
  申请人：BIOVITRUM AB

  公开号：WO2003004458A1

  公开（公告）日：2003-01-16

  The present invention relates to 2-(benzoylamino)benzoic acid derivatives of the formula (I), wherein the variants Ar, X and R are described in the specification. The said compounds modulate the activity of peroxisome proliferator-activated receptors (PPAR) α and/or γ, and are predicted to be useful in the treatment of metabolic diseases, e.g. type II diabetes.