Diethylketonmethylhydrazon | 51658-43-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Diethylketonmethylhydrazon
• 英文别名: N-(pentan-3-ylideneamino)methanamine
• CAS: 51658-43-6
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: KOWWJEHTOYGQGK-UHFFFAOYSA-N

物化性质

• 沸点：
  148.0±23.0 °C(Predicted)
• 密度：
  0.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Diethylketonmethylhydrazon 在 三氯化磷 作用下， 生成 5-Ethyl-2,4-dimethyl-2H-[1,2,3]diazaphosphole
  参考文献：
  名称：

  Baccolini, Graziano, Journal of the Chemical Society. Perkin transactions I, 1989, p. 1053 - 1056

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基肼 、 3-戊酮 以 苯 为溶剂， 反应 3.0h， 生成 Diethylketonmethylhydrazon
  参考文献：
  名称：

  Synthesis of 2-alkenylpyrazol-3(2H)-one derivatives under mild conditions

  摘要：

  The title compounds have been synthesized by a one-pot two-stage reaction of PCI,, ketone methyl-hydrazones and methyl acetoacetate. Both stages were carried out at room temperature and the corresponding 2-alkenyl-1,5-dimethylpyrazol-3(2H)-ones 5, which are an unknown series of pyrazolones, were obtained in good yields. Use of a variety of enolizable ketones has shown that the reaction always occurs with the predominance of the (E)-isomer. X-Ray structure determinations of an (E)- and a (Z)-derivative [(E)-5c.HCl and (Z)-5b] permitted the assignment of their structures. The aromaticity of these derivatives is discussed.

  DOI：

  10.1039/p19920001729

文献信息

• Thiazolyl-Dihydro-Indazoles
  申请人：McCONNELL Darryl

  公开号：US20120108567A1

  公开（公告）日：2012-05-03

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）的化合物，其中R1到R3的定义如权利要求书中所述，适用于治疗由过度或异常细胞增殖所表征的疾病，并且其用于制备具有上述特性的药物。
• Yandovskii,V.N.; Klindukhova,T.K., Journal of Organic Chemistry USSR (English Translation), 1974, vol. 10, p. 735 - 739
  作者：Yandovskii,V.N.、Klindukhova,T.K.

  DOI：——

  日期：——
• Bis-Heterocycles. Part II. Tetrahydro-3,3'-bi(1,2,4,5-oxatriazines)
  作者：Mohammed M. Abadleh、Mustafa M. El-Abadelah、Firas F. Awwadi、Monther S. Zreid

  DOI：10.3987/com-18-14015

  日期：——

  A new set of tetrahydro-3,3'-bi(1,2,4,5-oxatriazines) 3a-e has been prepared via condensation reaction of alkanone- and cycloalkanone N-methylhydrazones with bis-nitrile oxide. Structures of the synthesized bis-heterocycles are based on IR, NMR and MS spectral data and further by single-crystal X-ray diffraction analysis for compounds 3a and 3d. Compound 3c exhibited inhibitory activity against butyrylcholinesterase (BChE) with IC50 = 1.75 x 10(-5) mu M.
• BACCOLINI, GRAZIANO, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 1053-1056
  作者：BACCOLINI, GRAZIANO

  DOI：——

  日期：——
• Cyclic Amine Compounds and Agents for Pest Control
  申请人：Hamamoto Isami

  公开号：US20090259046A1

  公开（公告）日：2009-10-15

  Agents for pest control comprising cyclic amine compounds represented by the formula (1) or salts thereof or N-oxides thereof as an active ingredient, wherein Cy 1 represents an unsubstituted or substituted 5-membered heterocycle or unsubstituted or substituted group represented by the formula (a) below, wherein Y 1 and Y 2 each independently represents nitrogen or carbon and symbol * represents the bonding positions.