(2,6-Dibromo-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-isobutyl-amine | 74544-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,6-Dibromo-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-isobutyl-amine
• 英文别名: N-(2,6-dibromophenyl)-N-(2-methylpropyl)-4,5-dihydro-1H-imidazol-2-amine
• CAS: 74544-87-9
• 化学式: C₁₃H₁₇Br₂N₃
• 分子量: 375.106
• InChiKey: INTCECRXYWAQOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2,6-二溴苯基)-4,5-二氢-1H-咪唑-2-胺 以17%的产率得到
  参考文献：
  名称：

  STAEHLE H.; DANIEL H.; KOEBINGER W.; LILLIE C.; PICHLER L., J. MED. CHEM., 1980, 23, NO 11, 1217-1222

  摘要：

  DOI：

文献信息

• Chemistry, pharmacology, and structure-activity relationships with a new type of imidazolines exerting a specific bradycardic action at a cardiac site
  作者：Helmut Staehle、Helmut Daniel、Walter Kobinger、Christian Lillie、Ludwig Pichler

  DOI：10.1021/jm00185a013

  日期：1980.11

  The reaction of alkyl halides with 2-(arylimino)imidazolidines (I) leads to imidazoline derivatives II, in which the side chain is situated at the bridge nitrogen atom between the phenyl group and the imidazoline ring. The new imidazolines (II) exert a specific bradycardic action at a cardiac site. Syntheses and pharmacology are shown and structure-activity relationships discussed. The results reveal that the imidazoline derivatives (II) represent a class of compounds with a novel type of cardiac action.