5-(Bromomethyl)-2-methoxybenzoic acid | 865757-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(Bromomethyl)-2-methoxybenzoic acid
• CAS: 865757-45-5
• 化学式: C₉H₉BrO₃
• 分子量: 245.073
• InChiKey: HNRLXYNEJIXLGO-UHFFFAOYSA-N

物化性质

• 沸点：
  365.1±32.0 °C(Predicted)
• 密度：
  1.576±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(Bromomethyl)-2-methoxybenzoic acid 、 (7S)-7-氨基-1,2,3-三甲氧基-10-甲硫基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-5-(bromomethyl)-2-methoxy-N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)benzamide
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054
• 作为产物：
  描述：

  5-(溴甲基)-2-甲氧基苯甲酸甲酯 在 水 作用下， 以 甲醇 为溶剂， 生成 5-(Bromomethyl)-2-methoxybenzoic acid 、 2-Methoxy-5-(hydroxymethyl)benzoesaeure
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054

文献信息

• Visible-light photoinitiators and uses thereof
  申请人：Novartis AG

  公开号：US10324311B2

  公开（公告）日：2019-06-18

  Described herein are acyl germanium photoinitiator for cost-effective and time-efficient method for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a method for making UV-absorbing contact lenses made by using an acyl germanium photoinitiator of the invention.

  本发明所描述的酰基锗光引发剂用于生产具有成本效益和时间效率的紫外线吸收隐形眼镜的方法，该隐形眼镜能够阻挡紫外线（"UV"）辐射和波长为 380 纳米至 440 纳米的可选（但优选）紫外线辐射，从而在一定程度上保护眼睛免受紫外线辐射和潜在紫外线辐射的伤害。本发明还提供了一种使用本发明的酰基锗光引发剂制造紫外线吸收隐形眼镜的方法。
• GUANIDINOBENZOIC ACID COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2757093B1

  公开（公告）日：2016-12-07
• NOVEL PYRIMIDIN DERIVATIVES
  申请人：AstraZeneca UK Limited

  公开号：EP1000038A1

  公开（公告）日：2000-05-17
• VISIBLE-LIGHT PHOTOINITIATORS AND USES THEREOF
  申请人：Alcon Inc.

  公开号：EP3303415B1

  公开（公告）日：2022-12-28
• US6200981B1
  申请人：——

  公开号：US6200981B1

  公开（公告）日：2001-03-13