2-iodo-N-(4-phenylbutyl)acetamide | 1009621-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-iodo-N-(4-phenylbutyl)acetamide
• CAS: 1009621-83-3
• 化学式: C₁₂H₁₆INO
• 分子量: 317.17
• InChiKey: NIUZJICCIIUNAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  氯化碘乙酸 、 苯基-4-丁胺 以 乙醚 为溶剂， 反应 1.0h， 以16%的产率得到2-iodo-N-(4-phenylbutyl)acetamide
  参考文献：
  名称：

  Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy

  摘要：

  Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor Mile, and two other cysteine containing peptides. The electrospray response of each tagged peptide was compared against the same peptide alkylated with iodoacetamide. E-76 peptide alkylated with the synthesized tags demonstrated an increase in electrospray response of up to 429 times when compared to that alkylated with iodoacetamide.

  DOI：

  10.1021/ja076849y

文献信息

• Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy
  作者：D. Keith Williams、Corey W. Meadows、Ibrahim D. Bori、Adam M. Hawkridge、Daniel L. Comins、David C. Muddiman

  DOI：10.1021/ja076849y

  日期：2008.2.1

  Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor Mile, and two other cysteine containing peptides. The electrospray response of each tagged peptide was compared against the same peptide alkylated with iodoacetamide. E-76 peptide alkylated with the synthesized tags demonstrated an increase in electrospray response of up to 429 times when compared to that alkylated with iodoacetamide.