1-(4-Bromo-benzyl)-3-(2-hydroxy-ethyl)-thiourea | 74787-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Bromo-benzyl)-3-(2-hydroxy-ethyl)-thiourea
• 英文别名: 1-[(4-Bromophenyl)methyl]-3-(2-hydroxyethyl)thiourea
• CAS: 74787-66-9
• 化学式: C₁₀H₁₃BrN₂OS
• 分子量: 289.196
• InChiKey: PEZZCVAREURCJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-Bromo-benzyl)-dithiocarbamic acid methyl ester 、 C.I.酸性橙108 以 异丙醇 为溶剂， 反应 8.0h， 以63.1%的产率得到1-(4-Bromo-benzyl)-3-(2-hydroxy-ethyl)-thiourea
  参考文献：
  名称：

  Reiter; Toldy; Schafer, European Journal of Medicinal Chemistry, 1980, vol. 15, # 1, p. 41 - 53

  摘要：

  DOI：

文献信息

• Alpha-2B adrenergic receptor agonist and serotonin-norepinephrine reuptake inhibitor compositions for treating chronic pain
  申请人：Allergan, Inc.

  公开号：EP2428207A1

  公开（公告）日：2012-03-14

  Disclosed herein is a pharmaceutical composition comprising serotonin-norepinephrine reuptake inhibitor and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of treating pain using the composition and compounds comprising it are also disclosed.

  本文公开了一种药物组合物，其中包含血清素-去甲肾上腺素再摄取抑制剂和α-2B受体激动剂。该组合物对治疗慢性疼痛有效，还公开了使用该组合物和包含该组合物的化合物治疗疼痛的方法。
• REITER J.; TOLDY L.; SCHAEFER I.; SZONDY E.; BORSY J.; LUKOVITS I., EUR. J. MED. CHEM.- CHIM. THER., 1980, 15, NO 1, 41-53
  作者：REITER J.、 TOLDY L.、 SCHAEFER I.、 SZONDY E.、 BORSY J.、 LUKOVITS I.

  DOI：——

  日期：——
• ALPHA-2B RECEPTOR AGONIST AND 5HT4 SEROTONIN RECEPTOR COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
  申请人：Brooks Gregory F.

  公开号：US20080153825A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a 5-HT4 serotonin receptor agonist and an alpha-2B receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods of treating such disorders using the composition and compounds comprising it are also disclosed.
• ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN
  申请人：Gil Daniel W.

  公开号：US20080153874A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a pain-relieving anticonvulsant and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of treating chronic pain using the composition and the compounds comprising it are also disclosed.
• ALPHA-2B RECEPTOR AGONIST AND ACID REDUCER COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
  申请人：Brooks Gregory F.

  公开号：US20080153881A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising an acid reducer and an alpha-2B receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods of treating such disorders using the composition and compounds comprising it are also disclosed.